Practical approach to analgesia and sedation in the neonatal intensive care unit
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Cited by (68)
Pain management in newborns
2014, Clinics in PerinatologyCitation Excerpt :In summary, this drug should be used for sedation without analgesia and with caution in preterm and young term neonates. Acetaminophen inhibits the cyclooxygenase-2 (COX-2) enzymes in the brain; it has been well studied in newborns.207 It is frequently used in conjunction with other types of pain relief to decrease opioid use, especially for postsurgical pain.208
Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response
2013, Journal of PediatricsAnesthesia and Analgesia in the NICU
2012, Clinics in PerinatologyCitation Excerpt :Opioids are commonly used in modern NICUs.50 They provide procedural pain relief, such as for intubation premedication51–53; relief from chronic pain, such as necrotizing enterocolitis54; and ventilation.16,55,56 Several studies and reviews have pointed to the conclusion that they should be used selectively.
Drugs of Choice for Sedation and Analgesia in the Neonatal ICU
2009, Clinics in PerinatologyCitation Excerpt :Thus with intermittent bolus or continuous administration this drug can accumulate in young immature neonates, leading to toxicity.55 Acetaminophen acts by inhibiting the cyclo-oxygenase (COX) enzymes in the brain and has been well studied in newborns.16 It is useful for mild pain, in conjunction with other pain relief, or after circumcision.56
Utilization of analgesics, sedatives, and pain scores in infants with a prolonged hospitalization: A prospective descriptive cohort study
2009, International Journal of Nursing StudiesDrugs of Choice for Sedation and Analgesia in the Neonatal ICU
2009, Clinics in Perinatology