CommentaryPirfenidone in idiopathic pulmonary fibrosis
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New developments in the therapy of pulmonary fibrosis
2009, Advances in PharmacologyCitation Excerpt :However, this finding was questioned by Nagai, Handa, and Kim (2008). In laboratory studies IFNγ-1b has been shown to inhibit collagen synthesis, reduce the expression of profibrotic cytokines, and inhibit fibroblast proliferation (Eickelberg et al., 2001; Narayanan, Whitney, Souza, & Raghu, 1992). During the last decade, clinical studies with IFNγ-1b in patients with IPF produced some favorable, but largely negative, results (Antoniou et al., 2005, 2006, 2008; Nagai et al., 2008; Raghu, 2006; Raghu et al., 2004; Ziesche, Hofbauer, Wittmann, Petkov, & Block, 1999).
Pirfenidone inhibits early myointimal proliferation but has no effect on late lesion size in rats
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