HypothesisINTERACTION OF HLA MOLECULES WITH NON-IMMUNOLOGICAL LIGANDS AS AN EXPLANATION OF HLA AND DISEASE ASSOCIATIONS
References (27)
- et al.
Lancet
(1974) - et al.
Lancet
(1975) - et al.
Immunochem.
(1973) Transplantn Rev.
(1975)Biology of the Mouse Histocompatibility-2 Complex
(1975)Transplantn Rev.
(1974)- et al.
Monogr. hum. Genet.
(1975) Folia biol., Praha
(1968)Nature
(1972)
Trans plantn Rev.
Scand. J. Immun.
Cited by (75)
Adaptive threshold-stochastic resonance (AT-SR) in MHC clusters on the cell surface
2020, Immunology LettersCitation Excerpt :Hetero-associations of MHCI with the MHCII, ICAM-1, tetraspan molecules, transferrin receptor, and the interleukin-2 and -15 receptor subunits (α, β, γc) have been described on the surface of several cancerous cell lines of lymphoid (HUT-102B2, Kit-225 K6 T-lymphoblasts, and JY B-lymphoblast), colorectal (LS174 T) and uveal origin (OCM-1, OCM-3), as well as on the CD4+ T-cells from the peripheral blood and lymph nodes of patients in colorectal cancer and Crohn’s disease [1–7]. Although, the above observations are well described by the current concept of membrane organization according to which the lipid-rafts play a fundamental role in holding together the receptor clusters, the specific role for the core element MHCI and MHCII molecules in these clusters has not been clarified yet („MHC enigma”) [8–13]. In addition to their conventional roles in immune-recognition, a passive role in stabilising lipid rafts, as well as a „non-classical” role in signal-transduction (with signal-messengers such as ZAP70, p56lck, Tyk2, PI3K) aiming at modifying signaling thresholds and ensuring signal amplification – e.g. through increasing the effective binding surface of nearby receptors – can be assumed [14–19].
Open conformers: the hidden face of MHC-I molecules
2007, Trends in ImmunologyCitation Excerpt :The view that MHC-I open-up was a mechanism enabling the heavy chain to cis-associate with a new receptor and regulate its function was proposed 20 years ago [18,23,24]. It was preceded by a seminal essay postulating that HLA-I molecules have hidden functions related to the regulation of ligand–receptor interactions that impact on disease development [70], with the subsequent work of Michael Edidin, Lennart Olsson and collaborators moving this field forward [18,23–25,51,71,72]. For many years, the cis-associations between MHC-I molecules and hormone receptors were puzzling owing to the lack of data on their functional significance [24].
HLA antigens in chronic schizophrenia
1991, Biological PsychiatryFailure to find interference between anti-HLA antibodies and chlorpromazine
1990, Biological PsychiatryHLA antigens, epilepsy and cytomegalovirus infection
1988, Brain and Development