PLASMA-ZINC IN HEALTH AND DISEASE

doi:10.1016/S0140-6736(70)90701-4

The Lancet

Volume 295, Issue 7642, 14 February 1970, Pages 322-324

https://doi.org/10.1016/S0140-6736(70)90701-4 Get rights and content

Abstract

Plasma-zinc levels were measured by atomic-absorption spectrophotometry in healthy adults and children, in patients with a variety of diseases, in pregnancy, and in women taking oral contraceptives. The mean level was 96 μg. per 100 ml. for healthy adults and 89 μg. per 100 ml. for healthy children, and the concentration was constant with no significant variation attributable to sex, food consumption, or diurnal variation. Abnormally low values were obtained in alcoholic cirrhosis, other types of liver disease, active tuberculosis, indolent ulcers, uræmia, before and after a single hæmodialysis, myocardial infarct, non-tuberculous pulmonary infection, Down's syndrome, cystic fibrosis with growth retardation, growth-retarded Iranian villagers, pregnancy, and in women taking oral contraceptives. In cystic fibrosis without growth retardation and in inactive tuberculosis, there was no significant decrease. No conditions have been observed with a higher-than-normal plasma-zinc concentration.

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The difference may suggest that laying ducks are more susceptible to dietary Zn supplementation than are chickens. Plasma or serum zinc is the most frequently used index for evaluating the likelihood of zinc deficiency (Prasad et al., 1965; Hackley et al., 1968; Halsted and Smith, 1970; Pilch and Senti, 1985) although they may not necessarily reflect the cellular zinc status (Prasad et al., 1978; Milne et al., 1983; Lukaski et al., 1984). In the present study, plasma Zn level was lowest with the basal diet and increased quadratically with supplemental Zn, peaking in the 45 mg/kg treatment (total 84.4 mg/kg) before concentrations decreased.
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Zinc requirements and the risk and benefits of zinc supplementation
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Infact, Zn is a cofactor of the DNA and RNA polymerases required for protein synthesis in involved skin (Sung et al., 1996). Zinc is an integral part of as many as 40 metalloenzymes (Halstead and Smith, 1970). Among the most important antioxidant systems are the Super Oxide Dismutases (SOD) which contain zinc in their structure in addition to other minerals (Bannister et al., 1987).
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PLASMA-ZINC IN HEALTH AND DISEASE

Abstract

Am. J. Clin. Nutr.

Am. J. Clin. Nutr.

Am. J. Clin. Nutr.

Annls Sci. natn. botan. biol. végét.

Plant Physiol.

Am. J. Physiol.

Proc. Soc. exp. Biol. Med.

Am. J. Vet. Res.

J. Lab. clin. Med.

Nutrition Reviews

Gastroenteralogy

Lab. Invest.

Ann. intern. Med.