Lysozyme and α-Lactalbumin: Structure, Function, and Interrelationships

https://doi.org/10.1016/S0065-3233(08)60198-9Get rights and content

Publisher Summary

This chapter considers both the structure and function of α-lactalbumin and lysozyme in relation to each other, and also the potential significance of the studies in health and the pathology of disease, such as cancer. The chapter begins with brief report of the early discovery of the occurrence and isolation of these proteins and the elucidation of their function and homology, followed by a brief discussion of some problems in their isolation and the determination of their activity. Various aspects of their three-dimensional structures and their significance are also considered. Studies on the implications of their sequence similarities are summarized and also on the binding of metal ions, especially calcium (II), and consider their implications. A brief discussion of lactose synthase, an enzyme of which a-lactalbumin and galactosyltransferase are essential components, is provided. The determination of the three-dimensional structure of domestic hen egg-white lysozyme was the first elucidation of the X-ray crystal structure of an enzyme. Attention was directed to models for the α-lactalbumin structure based on the coordinates for lysozyme and on energy minimization programs.

References (562)

  • K.R. Acharya et al.

    J. Mol. Biol.

    (1989)
  • G. Alderton et al.

    J. Biol. Chem.

    (1946)
  • P. Andrews

    FEBS Lett.

    (1970)
  • C.B. Anfinsen et al.

    Adv. Protein Chem.

    (1975)
  • J.M. Armstrong et al.

    Biochim. Biophys. Acta

    (1967)
  • N. Arnheim et al.

    J. Mol. Biol.

    (1971)
  • N. Arnheim et al.

    J. Biol. Chem.

    (1973)
  • R. Arnon et al.

    J. Mol. Biol.

    (1971)
  • P.J. Artymiuk et al.

    J. Mol. Biol.

    (1981)
  • R. Aschaffenburg et al.

    J. Mol. Biol.

    (1972)
  • R. Aschaffenburg et al.

    J. Mol. Biol.

    (1972)
  • R. Aschaffenburg et al.

    J. Mol. Biol.

    (1979)
  • R. Aschaffenburg et al.

    Biochim. Biophys. Acta

    (1980)
  • M.Z. Atassi et al.

    Biochim. Biophys. Acta

    (1970)
  • H. Babad et al.

    J. Biol. Chem.

    (1964)
  • H. Babad et al.

    J. Biol. Chem.

    (1966)
  • S.K. Banerjee et al.

    J. Biol. Chem.

    (1975)
  • S.H. Banyard et al.
  • A.O. Barel et al.

    Biochim. Biophys. Acta

    (1972)
  • R. Barker et al.

    J. Biol. Chem.

    (1972)
  • T.E. Barman

    J. Mol. Biol.

    (1970)
  • T.E. Barman et al.

    Biochim. Biophys. Acta

    (1972)
  • J.E. Bell et al.

    J. Biol. Chem.

    (1976)
  • K. Bell et al.

    Biochim. Biophys. Acta

    (1970)
  • K. Bell et al.

    Comp. Biochem. Physiol.

    (1981)
  • L.R. Berger et al.

    Biochim. Biophys. Acta

    (1957)
  • J. Berthou et al.

    Biochim. Biophys. Acta

    (1974)
  • C.C.F. Blake

    Trends Biochem. Sci. (Pers. Ed.)

    (1983)
  • C.C.E. Blake et al.

    J. Mol. Biol.

    (1983)
  • M. Boesman-Finkelstein et al.

    FEBS Lett.

    (1982)
  • S.C. Bratcher et al.

    J. Biol. Chem.

    (1984)
  • K. Brew et al.

    J. Biol. Chem.

    (1970)
  • K. Brew et al.

    J. Biol. Chem.

    (1973)
  • U. Brodbeck et al.

    J. Biol. Chem.

    (1966)
  • U. Brodbeck et al.

    J. Biol. Chem.

    (1967)
  • C.L. Brooks et al.

    J. Mol. Biol.

    (1989)
  • R.C. Brown et al.

    Biochim. Biophys. Acta

    (1977)
  • W.J. Browne et al.

    J. Mol. Biol.

    (1969)
  • R.E. Canfield

    J. Biol. Chem.

    (1963)
  • R.E. Canfield et al.

    J. Biol. Chem.

    (1965)
  • E.P. Abraham et al.

    Nature (London)

    (1937)
  • K.R. Acharya D.I. Stuart D.C. Phillips H.A. McKenzie C.G. Teahan (1991)....
  • E.K. Achter et al.

    Biochemistry

    (1971)
  • AdebodunF. et al.

    Biochemistry

    (1989)
  • T. Alber et al.

    Nature (London)

    (1987)
  • A.G. Amit et al.

    Science

    (1986)
  • P.J. Andree et al.

    Biochim. Biophys. Acta

    (1978)
  • P.J. Andree et al.

    Biochemistry

    (1980)
  • A.T. Andrews

    J. Dairy Res.

    (1983)
  • P. Andrews

    Biochem. J.

    (1969)

    • Cited by (0)

    View full text
    Copyright © 1991 Academic Press Inc. Published by Elsevier Inc. All rights reserved.