Bronchiolitis obliterans, castleman's disease, and a bullous disease: Pemphigus vulgaris or paraneoplastic pemphigus?

doi:10.1016/S0046-8177(98)80024-5

Human Pathology

Volume 29, Issue 6, June 1998, Pages 657-658

https://doi.org/10.1016/S0046-8177(98)80024-5 Get rights and content

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Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation
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Histopathology of autoimmune bullous dermatoses: what's new?
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Citation Excerpt :
A more recent study described malignancy in 27% of affected patients [136]; a tentative paraneoplastic association has also been suggested by others [135,137,138]. Paraneoplastic pemphigus is the mucocutaneous manifestation of a heterogeneous autoimmune syndrome associated with underlying neoplasms, particularly non-Hodgkin lymphoma and Castleman disease [12,139]. The pathogenesis is complex, involving both cell-mediated and humoral immunity, with autoantibodies targeting a multitude of proteins such as desmogleins 1 and 3, BP180 and BP230, desmocollins, periplakin, and envoplakin, among others.
Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Overall, we aim to place emphasis on the histopathologic clues that can assist pathologists in differential diagnosis and review the updates in the literature.
Predominant stroma-rich feature in hyaline vascular variant of castleman disease is associated with paraneoplastic pemphigus: A 20-year retrospective study of 123 chinese patients with castleman disease
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CorrespondenceBronchiolitis obliterans, castleman's disease, and a bullous disease: Pemphigus vulgaris or paraneoplastic pemphigus?

Hum Pathol

J Eur Acad Dermatol Venereol

Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation

Jama

Correspondence
Bronchiolitis obliterans, castleman's disease, and a bullous disease: Pemphigus vulgaris or paraneoplastic pemphigus?