Elsevier

Transplantation Proceedings

Volume 30, Issue 7, November 1998, Pages 3127-3129
Transplantation Proceedings

Kidney Transplantation
Major infectious complications as a risk factor in kidney transplantation

https://doi.org/10.1016/S0041-1345(98)00964-6Get rights and content

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Materials and methods

One hundred and two renal transplants were performed between March 1986 and November 1996 at the Department of Surgery and Organ Transplantation, Institute of Medical Science, University of Tokyo. There were 67 males and 35 females, with a mean age of 37.7 ± 2.9 (SD) years (range 17 to 64 years). The mean duration of hemodialysis was 50.9 ± 9.2 months (range 0 to 220 months), and the mean duration of follow-up after transplantation was 59.9 ± 51.2 months (range 4 to 220 months). Sixty patients

Results

Fifty-four major infectious diseases occurred in 36 patients during the first 3 months following transplantation, and 50 major infectious diseases occurred in 30 patients after 4 months following transplant. Of 54 early infectious diseases, 27 were viral infections (14 CMV, 7 varicella zoster virus, 3 herpes simplex virus, 2 adenovirus, and 1 parvovirus), 16 were bacterial infections (all episodes were urinary tract infections except for one cholecystitis), 6 were fungal infections, and 5 were

Discussion

In this study, 35.3% of patients suffered one or more episodes of major infectious disease during the first 3 months following transplantation, and 33.3% of patients were affected after 4 months. All of 54 early infectious episodes including 14 CMV diseases were treated successfully. In the 90 patients we followed more than 1 year posttransplantation, we found two deaths (2.2%) directly attributable to infectious disease. We have previously reported that we lost 26 out of 225 transplant

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There are more references available in the full text version of this article.

Cited by (3)

  • Spectrum of severe infections in an Asian renal transplant population

    2004, Transplantation Proceedings
    Citation Excerpt :

    The documentation of 24 UTI among females in this RTX likely explains the higher female preponderance for infections in this study. As also with other series,6,7 CMV was the most common viral pathogen in our study. However, 61% (11 of 18) of the CMV infections in our study occurred after 6 months, beyond the traditional time frame of CMV infections and thus beyond the usual period of CMV prophylaxis.

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