Kidney TransplantationMajor infectious complications as a risk factor in kidney transplantation
Section snippets
Materials and methods
One hundred and two renal transplants were performed between March 1986 and November 1996 at the Department of Surgery and Organ Transplantation, Institute of Medical Science, University of Tokyo. There were 67 males and 35 females, with a mean age of 37.7 ± 2.9 (SD) years (range 17 to 64 years). The mean duration of hemodialysis was 50.9 ± 9.2 months (range 0 to 220 months), and the mean duration of follow-up after transplantation was 59.9 ± 51.2 months (range 4 to 220 months). Sixty patients
Results
Fifty-four major infectious diseases occurred in 36 patients during the first 3 months following transplantation, and 50 major infectious diseases occurred in 30 patients after 4 months following transplant. Of 54 early infectious diseases, 27 were viral infections (14 CMV, 7 varicella zoster virus, 3 herpes simplex virus, 2 adenovirus, and 1 parvovirus), 16 were bacterial infections (all episodes were urinary tract infections except for one cholecystitis), 6 were fungal infections, and 5 were
Discussion
In this study, 35.3% of patients suffered one or more episodes of major infectious disease during the first 3 months following transplantation, and 33.3% of patients were affected after 4 months. All of 54 early infectious episodes including 14 CMV diseases were treated successfully. In the 90 patients we followed more than 1 year posttransplantation, we found two deaths (2.2%) directly attributable to infectious disease. We have previously reported that we lost 26 out of 225 transplant
References (6)
- et al.
Jpn J Surg
(1989) - et al.
Ann Surg
(1987) - et al.
Transplantation
(1988)
Cited by (3)
Infectious complications in kidney transplant recipients: A single-center experience
2005, Transplantation ProceedingsSpectrum of severe infections in an Asian renal transplant population
2004, Transplantation ProceedingsCitation Excerpt :The documentation of 24 UTI among females in this RTX likely explains the higher female preponderance for infections in this study. As also with other series,6,7 CMV was the most common viral pathogen in our study. However, 61% (11 of 18) of the CMV infections in our study occurred after 6 months, beyond the traditional time frame of CMV infections and thus beyond the usual period of CMV prophylaxis.
Analytic reviews: Postoperative infectious complications of abdominal solid organ transplantation
2009, Journal of Intensive Care Medicine