Elsevier

Tetrahedron Letters

Volume 38, Issue 48, 1 December 1997, Pages 8359-8362
Tetrahedron Letters

Efficient synthesis of γ-methyl-capped guanosine 5′-triphosphate as a 5′-terminal unique structure of U6 RNA via a new triphosphate bond formation involving activation of methyl phosphorimidazolidate using ZnCl2 as a catalyst in DMF under anhydrous conditions

https://doi.org/10.1016/S0040-4039(97)10263-5Get rights and content

Abstract

P1-Methyl P3-(5′-guanosyl) triphosphate (CH3pppG), which exists as a unique structure at the 5′-terminal region of U6 RNA, was synthesized in an excellent yield by methyl phosphorimidazolidate (2c) with the bis(tetrabutylammonium) salt of GDP in the presence of ZnCl2 as an effective catalyst in dry DMF.

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