Manassantins A/B and saucerneol: novel biologically active lignoids from
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Cited by (47)
The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals
2017, Journal of Biological ChemistryCitation Excerpt :Manassantin is a dineolignan first isolated in 1983 by Rao and Alvarez (1) from the herb Saururus cernuus (Saururaceae).
Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations
2009, Bioorganic and Medicinal Chemistry LettersSaururus cernuus lignans - Potent small molecule inhibitors of hypoxia-inducible factor-1
2005, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Compound 1 is a previously unreported stereoisomer of manassantin B (6) that we now refer to as manassantin B1. Compound 2 was found to be the S. cernuus dineolignan manassantin A and compound 3 was determined to be the sesquineolignan 4-O-methylsaucerneol [15]. Both inactive compounds 4 (verrucosin) and 5 (austrobailignan-5) are monolignans [16–18].
Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis
2004, Bioorganic and Medicinal Chemistry LettersSuppression of RelA/p65 transactivation activity by a lignoid manassantin isolated from Saururus chinensis
2003, Biochemical PharmacologyCitation Excerpt :The purity of manassantins A and B was over 98% in a HPLC analysis. Physicochemical and spectral data of these compounds were comparable to previously reported values [19]. Nitric oxide was determined by measuring the amount of nitrite from cell culture supernatant as previously described [20].
Evaluation of Manassantin A Tetrahydrofuran Core Region Analogues and Cooperative Therapeutic Effects with EGFR Inhibition
2020, Journal of Medicinal Chemistry