Synthesis of heterocycles via sequential Pd/Ru-catalysed allene insertion–nucleophile incorporation–olefin metathesis
A three-component Pd(0)-catalysed cascade followed by ring-closing metathesis using a modified Grubbs catalyst proceeds in good overall yield.
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Acknowledgements
We thank Leeds University, GlaxoSmithKline, the EU and EPSRC for support.
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