Elsevier

Tetrahedron Letters

Volume 42, Issue 43, 22 October 2001, Pages 7629-7631
Tetrahedron Letters

First total synthesis of chapecoderin A: absolute configuration of the natural product

https://doi.org/10.1016/S0040-4039(01)01647-1Get rights and content

Abstract

A seco-labdane, chapecoderin A 1, has been synthesized starting from (S)-(+)-Wieland–Miescher ketone analogue 9. The absolute configuration has been determined to be 5S,10S.

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Acknowledgements

We thank Professor J. Kobayahi, Hokkaido University for providing spectral data of chapecoderin A 1. Thanks are also due to Tokyo Ohka Foundation for the Promotion of Science and Technology for partial financial support.

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