Elsevier

Steroids

Volume 13, Issue 5, May 1969, Pages 579-588
Steroids

Teratogenic compounds of Veratrum californicum (Durand) VII. The structure of the glycosidic alkaloid cycloposine

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Abstract

The structure was elucidated of a polar, glycosidic alkaloid, cycloposine, from Veratrum californicum, known to produce fetal cyclopia and related central nervous system malformations in sheep. Data from I.R., N.M.R., mass spectrometry and other means identified the structure as 3-glucosylcyclopamine. Thus, it is the glycoside of another teratogenic alkaloid, cyclopamine (11-deoxojervine) and hence 3-glucosyl-11-deoxojervine.

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  • Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album

    2019, Phytomedicine
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    Therefore, in recent years, the investigations on the anticancer properties of steroidal alkaloids of Veratrum species such as jervine, veratramine, cyclopamine have increased due to their teratogenic properties (Mistretta et al., 2003; Tang et al., 2008, 2010; Ghezali et al., 2013; Khanfar and El-Sayed, 2013; Torii et al., 2016). Jervine has also been used in the treatment of hypertension and heart disease (Keeler, 1969; Lee et al., 2007; Tang et al., 2008). In a recent study, Li et al., (2016) has reported the potent anti-inflammatory effect of jervine administrated intraperitoneally on carrageenan-induced paw edema, whereas there were no any data on inflammatory parameters and antioxidant levels.

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