Regular paperMultifunctional derivatives of metronidazole
References (18)
- et al.
Polymeric drug delivery systems
Drug Design
(1980) - et al.
Metronidazole phosphate - a water-soluble prodrug for parenteral solutions of metronidazole
J. Pharm. Sci.
(1982) - et al.
Prodrugs as drug delivery systems. XXVI. Preparation and enzymic hydrolysis of various watersoluble amino acid esters of metronidazole
Int. J. Pharm.
(1984) - et al.
Prodrugs as drug delivery systems. XXVII. Chemical stability and bioavailability of a water-soluble prodrug of metronidazole for parenteral adminstration
Int. J. Pharm.
(1984) Metronidazole: its past, present and future
J. Antimicrob. Chemother.
(1978)- et al.
Nitroimidazoles
Arzneium.-Forsch.
(1966) - et al.
Prodrugs. Part 2. Acylbenzoate esters of metronidazole
Eur. J. Med. Chem.
(1997) - et al.
Crotyl diazoacetate
Org. Syn. Coll.
(1973)
Cited by (11)
1-Methyl-5-nitroimidazolium chloride
2022, IUCrDataMetronidazole within phosphatidylcholine lipid membranes: New insights to improve the design of imidazole derivatives
2018, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :Our results show that substituents of the side chain of metronidazole are important for its interaction with phosphatidylcholine lipid membranes and, consequently, for the disturbance of the membrane. Several studies have been trying to develop new imidazole derivatives (e.g., [66–68]). Ultimately, the structure–toxicity relationship of metronidazole within phosphatidylcholine membranes can provide new insights for the modification and design of new imidazole derivatives with lower toxicity.
PEG-metronidazole conjugates: Synthesis, in vitro and in vivo properties
2005, FarmacoCitation Excerpt :Sterile solutions for infusion of 100.0 ml of 5 mg/ml of MTZ solutions are available. Several ester prodrugs of MTZ were reported in an effort to enhance its water solubility for parental administration, chemical stability, and membrane permeability and to diminish the susceptibility to enzymatic degradation [6–10]. In our research, a prodrug approach based on PEG as carrier polymer was adopted to overcome the solubility problem that prevents an easy formulation of parental solution and to modify the pharmacokinetic of the drug.
2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl 4-fluorobenzoate
2012, Acta Crystallographica Section E: Structure Reports OnlineMetronidazole citrate ester as the new prodrug of metronidazole
2017, Current Chemistry LettersEvaluation of antitumor activity and development of solid lipid nanoparticles of metronidazole analogue
2013, Journal of Biomedical Nanotechnology