Anti-TNFα therapy improves survival and ameliorates the pathophysiologic sequelae in acute pancreatitis in the rat
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Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways
2016, Biomedicine and PharmacotherapyCitation Excerpt :A plentiful of studies showed pro-inflammatory cytokines especially TNF-α, IL-1β and IL-6 were main reasons resulting in part damage of pancreas and progressing to systemic disease [18]. In pancreatitis, the levels of TNF-α, IL-1β and IL-6 were upregulated and the blockage on their increase can reduce the process of disease development [19,20]. Therefore, we determined the levels of TNF-α, IL-1β and IL-6 in acinar cells before and after the induction of AP.
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