Original ArticlesColor Doppler imaging discloses reduced ocular blood flow velocities in nonexudative age-related macular degeneration☆
Section snippets
Methods
Study subjects were eligible for inclusion if they had nonexudative macular degeneration, which is defined according to the International Classification System as a degenerative disorder in patients older than 50 years who have “soft drusen greater than 63 μm, hyperpigmentation and/or hypopigmentation of the retinal pigment epithelium, … or geographic atrophy of the retinal pigment epithelium.”5 Exclusion criteria included exudative macular degeneration in the study eye, which is defined by the
Results
Twenty-five age-related macular degeneration and 25 control subjects were evaluated. As summarized in Table 1, the mean age of the age-related macular degeneration subjects was 73.0 ± 10.9 years, whereas the mean age of the control subjects was 70.2 ± 8.5 years; there was no statistically significant difference in age. The age-related macular generation population comprised 15 men and 10 women and the control population comprised four men and 21 women, which represented a significant difference
Discussion
Investigators have traditionally believed that senescent retinal pigment epithelium accumulates metabolic debris from incomplete degradation of phagocytosed rod and cone membranes, which causes progressive engorgement of these retinal pigment epithelium cells, leading to drusen formation with subsequent progressive dysfunction of the remaining retinal pigment epithelium.1, 2 Healthy retinal pigment epithelium is necessary for maintenance of the choroid and choriocapillaris.9, 10, 11, 12, 13, 14
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This study was supported in part by a grant from the Fight for Sight research division of Prevent Blindness America, Schaumberg, Illinois (Dr Ciulla) by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York; and by National Institutes of Health, Bethesda, Maryland, grant EY10801 (Dr Harris). Dr Ciulla is the recipient of a Career Development Award from Research to Prevent Blindness, Inc.