An Immunohistochemical Study of Gelsolin Immunoreactivity in Corneal Amyloidosis
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Cited by (18)
Secondary corneal amyloidosis after perforating corneal trauma: A series of 5 cases and review of the literature
2015, Survey of OphthalmologyCitation Excerpt :Secondary localized corneal amyloidosis is an uncommon condition in which amyloid deposition occurs following chronic ocular surface inflammation and degeneration and may present as posterior polymorphous amyloid degeneration.20 Secondary localized corneal amyloidosis has also been associated with ocular trauma,22,30 trichiasis,2,5,6,15,23,25,45 keratoconus,4,30,36,39,41 and ocular inflammatory and degenerative conditions including interstitial keratitis,12 phlyctenular keratoconjunctivitis,30 syphilis,17 herpes keratitis,7,40 trachoma,16 congenital glaucoma,43 spheroidal elastotic (climatic droplet) keratopathy,26,28,34 pellucid marginal degeneration,18 and various corneal dystrophies including Fuchs' endothelial dystrophy38 and congenital hereditary endothelial dystrophy.26,27,44 There currently is no consensus on the mechanism of amyloid deposition in secondary localized corneal amyloidosis, though some hypotheses have been put forth.
Corneal melt in lattice corneal dystrophy type II after cataract surgery
2009, Journal of Cataract and Refractive SurgeryCitation Excerpt :Amyloid deposits are found in the anterior stroma, beneath a normal-appearing Bowman layer, and they often form scar tissue invading the subepithelial space,13 as in our case. Some investigators suggest that Meretoja syndrome can be diagnosed even retrospectively from corneal buttons subjected to histopathological study,13 whereas others say the accumulation of gelsolin is not confined to Meretoja syndrome and therefore is not pathognomonic; ie, it may be seen in various forms of amyloidosis.14 In a patient with corneal melt, the diagnostic approach should first exclude the possibility of an infection.
Ocular amyloidosis, with special reference to thehereditary forms with vitreous involvement
1995, Survey of OphthalmologyClinical and Histopathologic Features of Corneal Dystrophies in Japan
1995, OphthalmologyGelsolin immunoreactivity in corneal amyloid, wound healing, and macular and granular dystrophies
1993, American Journal of Ophthalmology
This study was supported in part by grant Lo 453/1-1 from the Deutsche Forschungsgemeinschaft, Bonn, Germany (Dr. Loeffler); core grant EY1792 from the National Eye Institute, Bethesda, Maryland; gifts from the Lions of Illinois Foundation, Maywood, Illinois; and an unrestricted research grant from Research to Prevent Blindness, Inc., New York, New York (University of Illinois at Chicago Eye Center).
Reprint requests to Mark O. M. Tso, M.D., Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, UIC Eye Center, University of Illinois at Chicago College of Medicine, 1855 W. Taylor St., Chicago, IL 60612.