Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease
Section snippets
Study design and outcome events:
In all, 1,017 patients with angiographically proven CAD were included in the study (defined as the presence of any diameter stenosis >30% according to coronary angiography by visual assessment in a major coronary artery; 42 patients had a diameter stenosis <50% [exclusion of those patients did not influence the study results]). Of the 1,017 patients, 994 (97.7%) were followed up a median of 2.2 years (maximum 3.1). Patients either presented at our clinic (86.5%) or were interviewed by telephone
Serum uric acid levels:
Of all of the study patients, 270 (26.5%) were women and 747 (73.5%) were men. The mean age ± SD of the study patients was 62 ± 10 years, the minimal age was 26 years, and the maximum age was 79 years; men were significantly younger than women (60.9 ± 10.2 vs 66.0 ± 8.9 years, p <0.001). The median (25th/75th quartiles) uric acid levels of all study patients was 357 μmol/L (303/422), whereas the uric acid levels of women were significantly lower than those of men (333 μmol/L [266/400] vs 363
Discussion
Serum uric acid was first reported to be a risk factor of atherosclerosis nearly half a century ago.1 Most, but not all, epidemiologic studies have suggested that there is an association between serum uric acid and CAD.2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 Some studies only found this association in women8, 10, 15 or found no association between serum uric acid and CAD.11, 12, 13 Several mechanisms may be involved in the association between uric acid and atherosclerosis. Uric acid may
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