Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis
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Keywords
Crystal structure
Isothermal titration calorimetry
Flavonoid
Wild type TTR
TTR V30M mutant
Amyloidosis
TTR amyloid inhibitor
Abbreviations
TTR
transthyretin
wt
wild type
V30M
Val30Met mutant
TTBS
thyroxin binding sites
HBP
halogen binding pocket
API
apigenin
LUT
luteolin
KAE
kaempferol
NAR
naringenin
CHR
chrisin
FIS
fisetin
QUE
quercetin
BAI
baicalein
T4
3,5,3′,5′-tetraiodothyronine
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