Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Graphical abstract
The synthesis of potent novel SYK inhibitors such as 17 (Ki = 8 nm) is reported.
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Present address: Novartis, Cambridge, MA, USA.
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Present address: Wyeth Reserch, Collegeville, PA, USA.
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