Chapter 15 - Nanopharmaceuticals to target antifilarials: Administration of old age drugs in a novel way
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Disruption of redox homeostasis with synchronized activation of apoptosis highlights the antifilarial efficacy of novel piperine derivatives: An in vitro mechanistic approach
2021, Free Radical Biology and MedicineCitation Excerpt :To deal with the disease, extensive research works have revealed handful of chemicals of both natural and synthetic origins that are known to be effective against the filarial parasites, however unfortunately they are not in use yet [5,6]. Diethyl carbamazine citrate, ivermectin, albendazole, doxycycline, suramin, levamisole are in use as antifilarials but are associated with major drawbacks such as poor solubility, small plasma half-life, wide bio-distribution, instability, low gastrointestinal tract uptake, rapid clearance by the immune cells, lower molecular weight, toxicity and various adverse side effects [7–10]. Therapeutic molecules with greater adulticidal effectiveness as well as less toxicity profiles are of choice.
Nano Drug Delivery Approaches for Lymphatic Filariasis Therapeutics
2022, Nanotechnology for Infectious Diseases
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