Ranunculales Medicinal Plants

Ranunculales Medicinal Plants

Biodiversity, Chemodiversity and Pharmacotherapy
2019, Pages 175-221
Ranunculales Medicinal Plants

Chapter 5 - Drug Metabolism and Disposition Diversity of Ranunculales Phytometabolites

https://doi.org/10.1016/B978-0-12-814232-5.00005-8Get rights and content

Abstract

In this chapter the current knowledge, as well as the challenges around the drug metabolism and pharmacokinetics (DMPK)-associated concerns in streamlining drug research and therapeutic use of Ranunculales phytometabolites are highlighted. Data from various in vivo and in vitro models are classified and discussed. DMPK characteristics of Ranunculales phytometabolites are summarized and presented according to the phylogenetic relationship of families and genera. This chapter also presents an overview of the complex interaction between DM enzymes/transporters and phytochemicals, as well as of the most advanced approaches in the relevant field. Since species-specific differences in DMPK exist, data obtained from animal studies may not be sufficient to predict DM reactions in humans. Omics-based methodologies (genomics, epigenomics, transcriptomics, proteomics, microbiomics, and metabolomics) should be used to enhance the reliability of DMPK prediction. The fluorescent probes may bridge the gap between conventional models and in vivo clinical studies in humans and provide a consistent basis for DMPK assay development.

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