Sirtuins in mechanistic target of rapamycin complex 1 signaling

Abstract

Sirtuins are a group of enzymes involved in a great variety of important cellular processes such as autophagy, cell growth, metabolism, aging, and many others. However, under certain circumstances, which are not completely understood, there is an alteration in those functions controlled by the sirtuins. These changes affect the formation and/or the progression of conditions including cancer, neurodegeneration, metabolic disturbances, and many others. These enzymes are key protective factors for the appearance of several disorders and the maintenance of cellular homeostasis. In this chapter we have analyzed the role of the different sirtuins in the appearance and development of different diseases.