European Journal of Cancer Part B: Oral Oncology
PaperStudies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis
References (27)
- et al.
Two-phase carcinogenesis in hamster buccal pouch
Oral Surg
(1982) - et al.
Epithelial dysplasia produced by carcinogen pretreatment and subsequent wounding
Oral Surg Oral Med Oral Pathol
(1989) - et al.
Oral lesions, genotoxicity and nitrosamines in betel quid chewers with no obvious increase in oral cancer risk
Cancer Lett
(1986) - et al.
Slaked lime and betel nut cancer in Papua New Guinea
Lancet
(1992) An epidemiological study of oral and pharyngeal cancer in central and south-east Asia
Bull WHO
(1966)A statistical study of oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: a preliminary report
J Formosan Med Assoc
(1976)- et al.
Carcinogenic effect of a dimethylsulphoxide extract of betel nut on the mucosa of the hamster buccal pouch
Nature
(1972) - et al.
Betel quid chewing and oral cancer: experimental studies on hamsters
Int J Cancer
(1979) - et al.
A statistical study on 234 cases of oral carcinoma
J Otolaryngol Soc ROC
(1984) - et al.
A study of betel quid carcinogenesis—VIII. Carcinogenicity of 3-(methylnitrosamino) propionaldehyde in F344 rats
Carcinogenesis
(1992)
Studies on Taiwan betel quid Carcinogenicity in hamster cheek pouch
Chinese Dent J
Experimental carcinogenesis in the cheek pouch of the Syrian hamster
J Dent Res
The effect of a carcinogen (DMBA) applied to the hamster's buccal pouch in combination with croton oil
Oral Surg
Cited by (35)
Arecoline N-oxide initiates oral carcinogenesis and arecoline N-oxide mercapturic acid attenuates the cancer risk
2021, Life SciencesCitation Excerpt :Approximately 80% of oral cancer patients are associated with BQ chewing in Taiwan [8]. Several findings revealed that the areca nut might be performed as a promoter, not an initiator for oral carcinogenesis [9–11]. Then, our team has reported that the arecoline N-oxide (ANO) revealed higher toxicity in oral potentially malignant disorders (OPMD) inductive activity in the C57BL/6 mice model [12].
Biotechnological intervention in betelvine (Piper betle L.): A review on recent advances and future prospects
2016, Asian Pacific Journal of Tropical MedicineCitation Excerpt :Despite of its medicinal uses, since long time betelvine has been a crucial point of argument that the consumption of betel leads to oral cancer. In many experiments, several scientists have proved that chewing of betel leaves along with areca nut, catechu, slaked lime and often tobacco induces cancer [19–25]. In contrary scientific studies have shown that betel leaf is itself devoid of mutagenic and carcinogenic effects.
Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components
2016, Journal of the Formosan Medical AssociationCitation Excerpt :This result suggests that ANE is not a strong complete carcinogen, not simulating the well-known complete carcinogen MCA that may induce transformed foci alone. BQ components have been suggested to be tumor promoters by using both in vitro and in vivo models.26–29 Previous studies have found that BQ extract may promote the transformation of JB6 cells and can be a tumor promoter.27
Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility
2007, Oral OncologyCitation Excerpt :There are about 200–600 million BQ chewers in the world, including Taiwan. More than 2400 new cases of oral cancer are diagnosed each year in Taiwan due to the prevalent use of BQ.20,21 There are several distinct compositions of BQ, among which areca nut is the essential component, whose extract induces growth arrest and senescence-associated phenotypes in human oral keratinocyte.22
The mRNA profile of genes in betel quid chewing oral cancer patients
2004, Oral Oncology