Cadherins in cancer: implications for invasion and metastasis

doi:10.1016/0955-0674(93)90029-P

Current Opinion in Cell Biology

Volume 5, Issue 5, October 1993, Pages 806-811

https://doi.org/10.1016/0955-0674(93)90029-P Get rights and content

Abstract

In order to understand the mechanisms of metastasis, one must first determine how cancer cells detach from primary tumors. It is known that cadherins are major cell-cell adhesion molecules in tumors as well as in normal tissues. The perturbation of cadherin function causes temporal or permanent disaggregation of tumor cells and may thus promote the invasion and metastasis of such cells.

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Cadherins in cancer: implications for invasion and metastasis

Abstract

Semin Cell Biol

Cell

J Cell Biol

J Cell Biol

Cancer Res

Cancer Res

Cell

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

Science

Protocadherins: A Large Family of Cadherin-Related Molecules in Central Nervous System

EMBO J

Unstable Expression of E-Cadherin Adhesion Molecules in Metastatic Ovarian Tumor Cells

Jpn J Cancer Res

E-Cadherin-Mediated Cell-Cell Adhesion Prevents Invasiveness of Human Carcinoma Cells

J Cell Biol

Down-Regulation of E-Cadherin Expression in Madin Darby Canine Kidney (MDCK) Cells Inside Tumors of Nude Mice

Int J Cancer

Flow Cytometric Analysis of the Expression of 9A3 Antigen, E-Cadherin and EGF Receptor in TMK-1 Stomach Cancer Cells

Int J Cancer

Genetic Manipulation of E-Cadherin Expression by Epithelial Tumor Reveals an Invasion Suppresser Role

Cell

Cell Adhesion Molecule Uvomorulin Expression in Human Breast Cancer Cell Lines: Relationship to Morphology and Invasive Capacities

Cell Growth Differentiation

Differential Cell Adhesion and Expression of N-Cadherin among Retinoblastoma Cell Lines

Invest Ophthalmol Vis Sci

Expression of Cadherin and NCAM in Human Small Cell Lung Cancer Cell Lines and Xenografts

Br J Cancer

Alterations in the Expression of Uvomorulin and Na+, K+-Adenosine Triphosphatase during Mouse Skin Tumor Progression

Am J Pathol

Decreased Expression of E-Cadherin in the Progression of Rat Prostatic Cancer

Cancer Res

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Mol Endocrinol

Morphoregulatory Activities of E-Cadherin and β-1 Integrins in Colorectal Tumour Cells

Br J Cancer

The E-Cadherin Promoter: Functional Analysis of a G.C-Rich Region and an Epithelial Cell-Specific Palindromic Regulatory Element

5′ Flanking Sequences of Mouse P-Cadherin Gene. Homologies to 5′ Sequences of E-Cadherin Gene and Identification of A First 215 bp Intron

J Mol Biol

Alterations in the Expression of Uvomorulin and Na⁺, K⁺-Adenosine Triphosphatase during Mouse Skin Tumor Progression