Involvement of calcitonin gene-related peptide in rat experimental colitis
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Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis
2012, Digestive and Liver DiseaseCitation Excerpt :NK-1 blockers were also beneficial in a T cell transfer model of chronic colitis [8]. A protective role of CGRP in colitis has been suggested by several pharmacological studies on TNBS colitis in rats [5,7,33]. In addition, knockdown by double-stranded RNA against the calcitonin receptor-like receptor for CGRP resulted in a significantly greater degree of oedema and necrosis than in sham-treated rats in TNBS colitis [34].
TRPA1 and substance P mediate colitis in mice
2011, GastroenterologyCitation Excerpt :In contrast, another neurokinin1 antagonist was ineffective in rat TNBS colitis.19,22 An opposite, protective, role of CGRP was suggested by several pharmacologic studies on rat TNBS colitis.20,22,71 In addition, knockdown by double-stranded RNA against the calcitonin receptor-like receptor for CGRP resulted in a significantly greater degree of edema and necrosis than in sham-treated rats with TNBS colitis.72
Colitis induces calcitonin gene-related peptide expression and Akt activation in rat primary afferent pathways
2009, Experimental NeurologyThe role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology
2004, European Journal of Pharmacology