Differential effects of the enantiomers R(−) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: Studies on depressed patients and normal controls
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2014, Pharmacology and TherapeuticsCitation Excerpt :In patients with depression S(+)oxaprotiline, but not R(−)oxaprotiline suppressed REM sleep. The antidepressive effects of S(+)oxaprotiline were superior to those of R(−)oxaprotiline (Steiger et al., 1993a) and only S(+)oxaprotiline was endocrinologically active as it stimulates GH. As discussed above GH stimulants have sleep promoting properties.
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2010, Journal of Psychiatric ResearchCitation Excerpt :S(+)oxaprotiline, but not R(−)oxaprotiline suppressed REM sleep in patients with depression. S(+)oxaprotiline was superior to R(−)oxaprotiline in its antidepressive effects (Steiger et al., 1993a). Whereas the effects of the vast majority of antidepressants on REM sleep are similar, there exist differences in their influence on sleep continuity and on nonREM sleep.
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Present address: Max Planck Institute of Psychiatry, Clinical Institute, Department of Psychiatry, Munich, Germany.