The antiviral role of nitric oxide
References (41)
- et al.
Systemic glutathione deficiency in symptom-free HIV-seropositive individuals
Lancet
(1989) - et al.
Inactivation of ribonucleotide reductase by nitric oxide
Biochem. Biophys. Res. Commun.
(1991) - et al.
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
Cell
(1995) - et al.
Interferon-gamma severely inhibits DNA synthesis of vaccinia virus in a macrophage cell line
Virology
(1994) - et al.
IFN-gamma-activated macrophages: detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and non-heme iron proteins
Biochem. Biophys. Res. Commun.
(1990) Redox signalling: nitrosylation and related target interactions of nitric oxide
Cell
(1994)- et al.
Redox regulation of fos and jun DNA-binding activity in vitro
Science
(1990) - et al.
In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes
Oncogene
(1991) - et al.
Inhibition of vesicular stomatitis virus infection by nitric oxide
J. Virol.
(1995) - et al.
Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease
J. Exp. Med.
(1995)
Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate
Am. Rev. Respir. Dis.
Both Epstein-Barr virus (EBV)-encoded transacting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter
Embo J.
Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication
J. Clin. Invest.
Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill avirulent M. avium: killing effector mechanism depends on the generation of reactive nitrogen intermediates
J. Leukocyte Biol.
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible
J. Clin. Invest.
Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1 infected patients
Biol. Chem. Hoppe-Seyler
Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1
J. Virol.
Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells
J. Cell. Biol.
Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration
J. Clin. Invest.
Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication
J. Virol.
Cited by (59)
Nitric oxide and viral infection: Recent developments in antiviral therapies and platforms
2021, Applied Materials TodayCitation Excerpt :NO-based antiviral therapies are broadly categorized into three strategies: 1) drugs that affect NOS regulation or endogenous production of NO; 2) gNO inhalation therapies; and 3) direct NO donor compounds. The bulk of existing antiviral NO therapeutic strategies target strains specific to respiratory tract infections, including: adenovirus, coronavirus, human respiratory syncytial virus, influenza A and B viruses, human parainfluenza viruses, and rhinovirus, among others [40,41,60]. Upper respiratory tract viral infections are often associated with increased lower airway exhaled NO, which as a host defense strategy has shown clearance ability against rhinoviruses [61,62], coronaviruses [63], herpes simplex virus (HSV) [64], and human influenza [65] in addition to many other bacterial, fungi, and viral strains [66].
The role of NO in COVID-19 and potential therapeutic strategies
2021, Free Radical Biology and MedicineCitation Excerpt :Upon treatment with SNAP, two new high-molecular weight peptides were found. It was suggested that NO changed the original cutting mode of cysteine proteases, thereby affecting production of the non-structural proteins, and terminating the replication process of viral RNA [61,64]. The effect of NO on S protein was also investigated.
Inhibition of oxidative metabolism by nitric oxide restricts EMCV replication selectively in pancreatic beta-cells
2020, Journal of Biological ChemistryCitation Excerpt :It is the inhibition of mitochondrial oxidative metabolism by nitric oxide and the lack of metabolic flexibility to compensate that protects β-cell against viral infection. When produced at iNOS-derived levels, nitric oxide has been shown to limit the replication of a wide range of viruses (45–50), and mice deficient in Nos2 have reduced capacity for viral clearance and die by overwhelming viremia when infected with picornaviruses such as coxsackievirus B4 (CVB4) (49). We have identified CCR5 as a signaling receptor for EMCV that stimulates macrophage expression of iNOS (51).
Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis
2020, Journal of Biological ChemistryNitric oxide stimulates a PKC-Src-Akt signaling axis which increases human immunodeficiency virus type 1 replication in human T lymphocytes
2019, Nitric Oxide - Biology and ChemistryInteractions between lactobacilli and chicken macrophages induce antiviral responses against avian influenza virus
2019, Research in Veterinary ScienceCitation Excerpt :It is possible that certain Lactobacillus strains may operate NO-independent mechanisms in inducing antiviral response in macrophages. Considering that NO is an effector antiviral molecule and that it has been shown to inhibit replication of a variety of viruses (Mannik, 1995), it is possible that NO production may have been one of the contributing factors to the observed reduction in AIV replication. Interferon-γ, produced mainly by T cells, is an important cytokine in macrophage activation and under certain conditions, macrophages by themselves can secrete IFN-γ that act in an autocrine or paracrine manner (Morita et al., 2002).