Elsevier

Research in Immunology

Volume 146, Issue 9, November–December 1995, Pages 693-697
Research in Immunology

The antiviral role of nitric oxide

https://doi.org/10.1016/0923-2494(96)84920-0Get rights and content

First page preview

First page preview
Click to open first page preview

References (41)

  • CameronM.L. et al.

    Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate

    Am. Rev. Respir. Dis.

    (1990)
  • Chevallier-GrecoA. et al.

    Both Epstein-Barr virus (EBV)-encoded transacting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter

    Embo J.

    (1986)
  • CroenK.D.

    Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication

    J. Clin. Invest.

    (1993)
  • DenisM.

    Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill avirulent M. avium: killing effector mechanism depends on the generation of reactive nitrogen intermediates

    J. Leukocyte Biol.

    (1991)
  • DrapierJ.C. et al.

    Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible

    J. Clin. Invest.

    (1986)
  • EckH.P. et al.

    Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1 infected patients

    Biol. Chem. Hoppe-Seyler

    (1989)
  • FlemingtonE. et al.

    Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1

    J. Virol.

    (1990)
  • GrangerD.L. et al.

    Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells

    J. Cell. Biol.

    (1982)
  • GrangerD.L. et al.

    Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration

    J. Clin. Invest.

    (1980)
  • HarrisN. et al.

    Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication

    J. Virol.

    (1995)
  • Cited by (59)

    • Nitric oxide and viral infection: Recent developments in antiviral therapies and platforms

      2021, Applied Materials Today
      Citation Excerpt :

      NO-based antiviral therapies are broadly categorized into three strategies: 1) drugs that affect NOS regulation or endogenous production of NO; 2) gNO inhalation therapies; and 3) direct NO donor compounds. The bulk of existing antiviral NO therapeutic strategies target strains specific to respiratory tract infections, including: adenovirus, coronavirus, human respiratory syncytial virus, influenza A and B viruses, human parainfluenza viruses, and rhinovirus, among others [40,41,60]. Upper respiratory tract viral infections are often associated with increased lower airway exhaled NO, which as a host defense strategy has shown clearance ability against rhinoviruses [61,62], coronaviruses [63], herpes simplex virus (HSV) [64], and human influenza [65] in addition to many other bacterial, fungi, and viral strains [66].

    • The role of NO in COVID-19 and potential therapeutic strategies

      2021, Free Radical Biology and Medicine
      Citation Excerpt :

      Upon treatment with SNAP, two new high-molecular weight peptides were found. It was suggested that NO changed the original cutting mode of cysteine proteases, thereby affecting production of the non-structural proteins, and terminating the replication process of viral RNA [61,64]. The effect of NO on S protein was also investigated.

    • Inhibition of oxidative metabolism by nitric oxide restricts EMCV replication selectively in pancreatic beta-cells

      2020, Journal of Biological Chemistry
      Citation Excerpt :

      It is the inhibition of mitochondrial oxidative metabolism by nitric oxide and the lack of metabolic flexibility to compensate that protects β-cell against viral infection. When produced at iNOS-derived levels, nitric oxide has been shown to limit the replication of a wide range of viruses (45–50), and mice deficient in Nos2 have reduced capacity for viral clearance and die by overwhelming viremia when infected with picornaviruses such as coxsackievirus B4 (CVB4) (49). We have identified CCR5 as a signaling receptor for EMCV that stimulates macrophage expression of iNOS (51).

    • Interactions between lactobacilli and chicken macrophages induce antiviral responses against avian influenza virus

      2019, Research in Veterinary Science
      Citation Excerpt :

      It is possible that certain Lactobacillus strains may operate NO-independent mechanisms in inducing antiviral response in macrophages. Considering that NO is an effector antiviral molecule and that it has been shown to inhibit replication of a variety of viruses (Mannik, 1995), it is possible that NO production may have been one of the contributing factors to the observed reduction in AIV replication. Interferon-γ, produced mainly by T cells, is an important cytokine in macrophage activation and under certain conditions, macrophages by themselves can secrete IFN-γ that act in an autocrine or paracrine manner (Morita et al., 2002).

    View all citing articles on Scopus
    View full text