Neuron
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
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Cited by (275)
Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands
2020, iScienceCitation Excerpt :The TrkC receptor is a key player in the development, selection, maintenance, health, phenotype, and function of motor neurons, vascular endothelium, and other cell types (Saragovi et al., 2009; Segal, 2003; Sendtner et al., 1996; Youn et al., 2003). The trkC gene can generate, through alternative splicing, mRNAs encoding for several isoforms (Tsoulfas et al., 1993). The full-length TrkC (TrkC-FL) protein intracellular domain has a tyrosine kinase catalytic domain, whereas the truncated TrkC.T1 protein lacks the kinase and most of the intracellular domain but gains a new exonic sequence (Figure 1A).
Rac1b regulates NT3-stimulated Mek-Erk signaling, directing marrow-isolated adult multilineage inducible (MIAMI) cells toward an early neuronal phenotype
2012, Molecular and Cellular NeuroscienceExpression and localisation of BDNF, NT4 and TrkB in proliferative vitreoretinopathy
2008, Experimental Eye ResearchCitation Excerpt :However, binding of NTs to these truncated receptors (reviewed in Reichardt and Farinas, 1997) does not cause activation of the intracellular pathway. Both the full-length and truncated forms of TrkB and TrkC receptors have been detected in neurons, while only truncated TrkB and TrkC isoforms have been detected in non-neuronal cells (Klein et al., 1990; Martin-Zanca et al., 1990; Middlemas et al., 1991; Tsoulfas et al., 1993; Valenzuela et al., 1993). The functions of truncated isoforms of TrkB and TrkC in non-neuronal cells may include presentation of neurotrophins to neurons.
Promoting neuron adhesion and growth
2008, Materials TodayNeurotrophic factor neurotrophin-4 regulates ameloblastin expression via full-length TrkB
2008, Journal of Biological ChemistryTrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions
2006, Developmental Biology
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