Mitochondrial studies in senescent mice—II. Specific activity, buoyant density, and turnover of mitochondrial DNA
References (23)
Methods in Enzymology
(1967)- et al.
Biochim. biophys. Acta
(1966) - et al.
Biochim. biophys. Acta
(1966) - et al.
Exp. Geront.
(1968) - et al.
Analyt. Biochem.
(1970) - et al.
Exp. Geront.
(1971) Exp. Geront.
(1969)- et al.
J. molec. Biol.
(1962) Exp. Geront.
(1970)- et al.
J. Gerontol.
(1960)
Science
Cited by (33)
Mitochondrial mutations and ageing: Can mitochondrial deletion mutants accumulate via a size based replication advantage?
2014, Journal of Theoretical BiologyCitation Excerpt :To our knowledge mtDNA half-life has only been measured in mice or rats, but never in humans. Furthermore, studies are both sparse and old (Gross et al., 1969; Huemer et al., 1971; Korr et al., 1998), or gave results completely incompatible with other studies (Collins et al., 2003). The situation regarding measurements of the mtDNA replication time is even worse.
Mathematical models of mitochondrial aging and dynamics
2014, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Deletions of more than 50% of the genome size have been observed,11 which could result in an equal reduction of replication time. However, the idea had also been questioned since the replication time of mtDNA is only 1–2 h106,107 and thus much shorter than the half-life of mtDNA, which is in the order of 1–3 weeks.108–110 It is therefore difficult to see how under those conditions mtDNA replication can be the rate-limiting step for mitochondrial growth.103,111
Rheb regulates mitophagy induced by mitochondrial energetic status
2013, Cell MetabolismCitation Excerpt :Yet early studies have proposed the existence of a basal degradation mechanism that contributes to mitochondrial turnover. It has been shown that mitochondria may be completely renewed within 14 days in different tissues and cell types (Huemer et al., 1971; Menzies and Gold, 1971). This renewal requires both mitochondrial biogenesis and degradation.
A network theory of ageing: The interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process
1996, Mutation Research - DNAging Genetic Instability and AgingMitochondrial mutations, cellular instability and ageing: modelling the population dynamics of mitochondria
1993, Mutation Research DNAging
- ∗
Present address: Molecular Disease Foundation, 22554 Ventura Blvd., Woodland Hills, Calif. 91364, U.S.A.