Plant-derived alkaloids active against Trypanosoma cruzi
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Cited by (30)
Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogs
2019, Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical DiseasesAntitrypanosomal and antileishmanial activities of novel N-alkyl-(1-phenylsubstituted-β-carboline)-3-carboxamides
2010, Biomedicine and PharmacotherapyBiological activity of 1,2,3,4-tetrahydro-β-carboline-3-carboxamides against Trypanosoma cruzi
2009, Acta TropicaCitation Excerpt :Natural and synthetic β-carbolines and tetrahydro-β-carboline alkaloids are well-known compounds that possess several biological properties, such as anticonvulsive, ansiolytic, sedative, antimicrobial, antithrombotic, anti-HIV, antiproliferative, insecticidal, and parasiticidal (Ishida et al., 2001; Lin et al., 2002; Castro et al., 2003; Takasu et al., 2004; Cao et al., 2005; Costa et al., 2006). This class of compounds has been tested in trypanocidal assays, and some reports have shown the activity of β-carbolines and tetrahydro-β-carbolines against T. cruzi (Calvin et al., 1987). In a previous work we demonstrated the activity of 1-(nitrophenyl)-tetrahydro-β-carbolines against epimastigote forms of T. cruzi (Tonin et al., 2008).
Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-β-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry
2009, European Journal of Medicinal ChemistryCitation Excerpt :Natural and synthetic β-carbolines and tetrahydro-β-carbolines alkaloids are well-known compounds that possess a variety of biological properties, such as anticonvulsive, ansiolytic, sedative, antimicrobial, antithrombotic, anti-HIV, antiproliferative, insecticidal, and parasiticidal [4–6]. In the recent years, this class of compounds has been tested in trypanocidal assays against T. cruzi [7–9]. The importance of the search for new effective chemotherapy agents for the treatment of Chagas disease together with the trypanocidal activity reported for tetrahydro-β-carboline alkaloids, lead us to study this class of compounds.
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors
2008, Bioorganic and Medicinal ChemistryChapter 2 Alkaloids with Antiprotozoal Activity
2008, Alkaloids: Chemistry and BiologyCitation Excerpt :A fully unsaturated pyridoindole ring system seems to be a necessary condition for optimal activity in these compounds. This could be associated with planarity of the molecule, its redox behavior or its electron density distribution, to mention three possible structural desiderata (254,256). Nevertheless, other mechanisms could be involved, since compounds such as harmaline (162), a dihydro-β-carboline, present greater antiprotozoal activity than fully aromatic compounds.