Diuretic activity of plants used for the treatment of urinary ailments in guatemala

doi:10.1016/0378-8741(87)90001-8

Journal of Ethnopharmacology

Volume 19, Issue 3, May 1987, Pages 233-245

https://doi.org/10.1016/0378-8741(87)90001-8 Get rights and content

Abstract

Through ethnobotanical surveys in Guatemala, about 250 plants were identified for use in the treatment of urinary ailments. From 67 of these, aqueous extracts were prepared to investigate their oral diuretic activity in albino rats after a dose equivalent to 1 $g kg$ of dried plant material. The trials demonstrated that in 33 cases urinary excretion was not significantly increased (< 90%), in 20 cases intermediate activity was seen (90–189%) and in 14 cases high diuretic activity was noted (> 189%). Control treatment increased urine output an average of 36% while 25 $mg kg$ hydrochlorothiazide treatment increased urine output by 286%. In a select group of the most used local plants, ethanol extracts were tested for their effect on urinary excretion of uric acid and electrolytes. Of these, three plants significantly increased uric acid excretion as did the reference drug, probenecid, 25 $mg kg$ .

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Nephroprotective plant species used in traditional Mayan Medicine for renal-associated diseases
2023, Journal of Ethnopharmacology
Citation Excerpt :
Therefore, extracts from C. edulis or isolated compounds should be carried out to explore the potential of this species as a nephroprotective agent. The leaves of S. torvum have been used to treat kidney pain, kidney infections, and urinary problems (Cáceres et al., 1987; Hitziger, 2016; Orantes-García et al., 2018; Pardo, 2011). Pretreatment of an ethanolic fruit extract (100 and 300 mg/kg) for 4 weeks demonstrated a nephroprotective effect in Wistar rats by reducing the serum creatinine and urea levels, increasing the renal antioxidant system (SOD and CAT), and suppressing the tubular necrosis, renal lesions and glomerular congestion induced by doxorubicin compared to the control group (Mohan et al., 2010).
The prevalence of kidney disease has increased rapidly in recent years and has emerged as one of the leading causes of mortality worldwide. Natural products have been suggested as valuable nephroprotective agents due to their multi-target and synergistic effects on modulating important proteins involved in kidney injury. There is a large number of plant species that have been used traditionally for kidney-related conditions in Mesoamerican medicine by different cultural groups that could provide a valuable source of nephroprotective therapeutic candidates and could lead to potential drug discovery.
This review aims to provide an overview of the currently known efficacy of plant species used traditionally in Mesoamerica by Mayan groups to treat kidney-related conditions and to analyze the phytochemical, pharmacological, molecular, toxicological, and clinical evidence to contribute to public health efforts and for directing future research.
Primary sources of plant use reports for traditional kidney-related disorders in Mesoamerica were searched systematically from library catalogs, theses, and scientific databases (PubMed, Google Scholar; and Science Direct), and were filtered according to usage frequency in Mayan groups and plant endemism. The database of traditional plants was further analyzed based on associations with published reports of the phytochemical, pharmacological, molecular, toxicological, and clinical evidence.
The most reported kidney-related conditions used traditionally in Mayan medicine involve reducing renal damage (a cultural interpretation that considers an inflammatory or infectious condition), cleaning or purifying the blood and kidney, reducing kidney pain, and eliminating kidney stones. A total of 208 plants used for kidney-related problems by 10 Mayan groups were found, representing 143 native species, where only 42 have reported pharmacological activity against kidney damage, mainly approached by in vitro and in vivo models of chemical- or drug-induced nephrotoxicity, diabetes nephropathy, and renal injury produced by hypertension. Nephroprotective effects are mainly mediated by reducing oxidative stress, inflammatory response, fibrosis mechanisms, and apoptosis in the kidney. The most common nephroprotective compounds associated with traditional Mayan medicine were flavonoids, terpenoids, and phenolic acids. The most widely studied traditional plants in terms of pharmacological evidence, bioactive compounds, and mechanisms of action, are Annona muricata L., Carica papaya L., Ipomoea batatas (L.) Lam., Lantana camara L., Sechium edule (Jacq.) Sw., Tagetes erecta L., and Zea mays L. Most of the plant species with reported pharmacological activity against kidney damage were considered safe in toxicological studies.
Available pharmacological reports suggest that several herbs used in traditional Mayan medicine for renal-associated diseases may have nephroprotective effects and consistent pharmacological evidence, nephroprotective compounds, and mechanisms of action in different models of kidney injury. However, more research is required to fully understand the potential of traditional Mayan medicine in drug discovery given the limited ethnobotanical studies and data available for most species with regards to identification on bioactive components, pharmacological mechanisms, and the scarce number of clinical studies.
Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview
2022, Journal of Ethnopharmacology
For thousands of years, different cultural groups have used and transformed natural resources for medicinal purposes focused on psychological or neurological conditions. Some of these are recognized as central nervous system (CNS) disorders and diseases, whereas other ethnopsychiatric interpretations are explained in culture-specific terms. In traditional Mayan medicine, several herbs have been part of treatments and rituals focused on cultural and ethnomedical concepts.
This study aims to provide a comprehensive overview of the medicinal plants used in Mesoamerica by traditional healers and Mayan groups to CNS disorders and associate the traditional use with demonstrated pharmacological evidence to establish a solid foundation for directing future research.
A systematic search for primary sources of plant use reports for traditional CNS-related remedies of Mesoamerica were obtained from library catalogs, thesis and scientific databases (PubMed, Scopus, Google Scholar; and Science Direct), and entered in a database with data analyzed in terms of the usage frequency, use by ethnic groups, plant endemism, and pharmacological investigation.
A total of 155 plants used for ethnopsychiatric conditions in Mesoamerica by Mayan groups were found, encompassing 127 native species. Of these, only 49 native species have reported in vitro or in vivo pharmacological analyses. The most commonly reported ethnopsychiatric conditions are related to anxiety, depression, memory loss, epilepsy, and insomnia. The extent of the scientific evidence available to understand the pharmacological application for their use against CNS disorders varied between different plant species, with the most prominent evidence shown by Annona cherimola, Justicia pectoralis, J. spicigera, Mimosa pudica, Persea americana, Petiveria alliacea, Piper amalago, Psidium guajava, Tagetes erecta and T. lucida.
Available pharmacological data suggest that different plant species used in traditional Mayan medicine may target the CNS, mainly related to GABA, serotonin, acetylcholine, or neuroprotective pathways. However, more research is required, given the limited data regarding mechanism of action at the preclinical in vivo level, identification of active compounds, scarce number of clinical studies, and the dearth of peer-reviewed studies.
Recent developments in stigma maydis polysaccharides: Isolation, structural characteristics, biological activities and industrial application
2020, International Journal of Biological Macromolecules
Citation Excerpt :
EUPS-2 exhibited a granular shape with a size ranged from 3 to 50 μm, which displayed higher antioxidant and anticancer activities than PS-2 showed a lumpish appearance with a size of 10–90 μm [32]. As an ingredient of medicine and diet, stigma maydis was used in functional and health products because of its abundant pharmacological effects, including the diuretic [1], anti-fatigue activity [4], as well as bedwetting and obesity [80,81]. Due to their various beneficial effects, stigma maydis have been widely exploited in medicines and healthy foods in China.
Stigma maydis, an ingredient of pharmaceuticals and healthy foods, has a long history of usage in China and some occidental countries. Polysaccharide (SMP) is supposed to be one of the major bioactive compounds in stigma maydis, which possesses immune-enhancement, antitumor, antioxidant, anti-fatigue, diuretic, liver protection, antihyperglycaemic and hypolipidemic activities. In this review, the current advancements on extraction, purification, structural characteristics and biological activities of polysaccharides were summarized. Their biological activities were introduced on the basis of vivo experiments, and some possible mechanisms were listed. Furthermore, industrial application of SMPs were reviewed and discussed. New perspectives for the future work of stigma maydis polysaccharide were also proposed.
A green and cost-effective approach for the production of gold nanoparticles using corn silk extract: A recoverable catalyst for Suzuki–Miyaura reaction and adsorbent for removing of dye pollutants
2019, Polyhedron
In this study, we have developed an eco-friendly and inexpensive method for the synthesis of gold nanoparticles immobilized on the Schiff-base functionalized SBA-15 by using of corn silk extract as a natural reducing agent. Appropriate analyses confirm the structure of this heterogeneous nanocomposite. This synthesized nanocomposite acts as a robust nanocatalyst for the selective production of biphenyls in Suzuki–Miyaura coupling reaction and a strong adsorbent for degradation of anionic and cationic dyes such as methyl orange and methylene blue. The results show that this composite leads to the formation of biphenyl derivatives in excellent yields even for less-active aryl halides such as chlorobenzene at mild conditions and efficient degradation of organic dyes (>99%) in a short time through a pseudo-first order kinetic model. Easy separation of this nanocomposite from the reaction mixture by applying an external magnet and its reusability for several times without significant loss in its activity, are the other advantages of this nanocomposite.
Bioactive isoquinoline alkaloids from Cissampelos pareira <sup>†</sup>
2019, Natural Product Research
The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5) and cycleanine (6). Magnoflorine (1) and magnocurarine (2) were isolated for the first time from C. pareira. A new, rapid, simple and sensitive UPLC method was developed for simultaneous quantification of five pure compounds (1–5). Seasonal variation study revealed higher content of these compounds during the rainy season. The chloroform (CPCF) and n-butanol (CPBF) fractions showed cytotoxic efficacy against KB cells. Among pure compounds, hayatinine (5) was found to be most active against KB and A549, while, cycleanine (6) against KB cells.
The Genus Hymenaea (Fabaceae): A Chemical and Pharmacological Review
2018, Studies in Natural Products Chemistry
Hymenaea (Fabaceae) is a genus greatly spread out from Central to South America. Plants of this genus are known as “jatobá,” “jetaí,” “jataí-uva,” and “jetaíba,” and are commonly used in traditional medicine. The tree trunks exude a resin, used in folk medicine for the treatment of several disorders. The aim of this study was to review the main publications on the genus Hymenaea, focusing on the pharmacological and chemical approaches. The biological activity and chemical research of the Hymenaea species were run through the main data banks available. The specific names of the genus and the species were used as keywords. There are some important ethnopharmaceutical studies on the Hymenaea species, reporting its use either as a decoction or as a syrup for coughing, anemia, bronchitis, inflammation, antioxidant, sinusitis, abdominal spasms, prostate, asthma, common cold, and lung problems, and the resin in a patch for healing wounds. In some ethnopharmacological articles, the genus was one of the most cited by the population. The parts of the plants cited are the barks, resin, stem, and epicarp. This genus was tested for several activities, and many results were positive. A main chemical characteristic of Hymenaea species is the essential content of diterpenoids in the bark extracts and resin. Flavonoids, amino acids, fatty acids, carbohydrates, coumarins, sesquiterpenes, steroids, misc lactones, chromones, and diterpenes were found in its composition. Important studies were developed with Hymenaea plants, and the research showed in this review justifies its traditional use for the treatment of several health problems. Among important medicinal plants, Hymenaea is a genus with a great chemical and pharmacological potential. New research data would improve the knowledge and the application of this genus, contributing to its safe use and the development of new medicinal alternatives.

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^☆: Preliminary data was presented at the XII Panamerican Congress of Pharmacy and Biochemistry held in Guatemala, December 1–7, 1985.

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Journal of Ethnopharmacology

Abstract

References (34)

Maya medicinal plants of San José Succotz, Belize

Journal of Ethnopharmacology

The intensely sweet herb, Lippia dulcis Trev.; Historical uses, field inquiries, and constituents

Journal of Ethnopharmacology

Plants used as abortifacients and emmenagogue by Spanish New Mexicans

Journal of Ethnopharmacology

Ethnopharmacology of some Buddleja species

Journal of Ethnopharmacology

Relación de Unos Aspectos de la Flora Util de Guatemala

Acción Diurética y Antimicrobiana de Algunos Vegetales del Género Smilax (Tesis)

Acción Diurética de Algunas Plantas de Guatemala (Tesis)

Sistema para la revalidación, investigación y comercialización de las plantas medicinales en Guatemala

Estudios sobre medicina popular en Guatemala

Medicina Tradicional

Estudios colaborativos y transferencia tecnológica sobre plantas medicinales entre USAC/CEMAT

Perspectiva

Usos de las Plantas Medicinales de México

Las plantas medicinales del departamento de Alta Verapaz

Anales de la Sociedad de Geografía e Historia de Guatemala

Las plantas medicinales del departamento de Alta Verapaz

Anales de la Sociedad de Geografía e Historia de Guatemala

Especies Utiles de la Flora Salvadoreña

Clinical Chemistry: Principles and Technics

Botanical remedies of South and Central America, and the Caribbean: an archival analysis

Journal of Ethnopharmacology

Aspectos de la medicina popular en el área rural de Guatemala

Guatemala Indígena

Cited by (143)

Nephroprotective plant species used in traditional Mayan Medicine for renal-associated diseases

Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview

Recent developments in stigma maydis polysaccharides: Isolation, structural characteristics, biological activities and industrial application

A green and cost-effective approach for the production of gold nanoparticles using corn silk extract: A recoverable catalyst for Suzuki–Miyaura reaction and adsorbent for removing of dye pollutants

Bioactive isoquinoline alkaloids from Cissampelos pareira <sup>†</sup>

The Genus Hymenaea (Fabaceae): A Chemical and Pharmacological Review

Diuretic activity of plants used for the treatment of urinary ailments in guatemala☆

Abstract

Journal of Ethnopharmacology

Journal of Ethnopharmacology

Journal of Ethnopharmacology

Journal of Ethnopharmacology

Relación de Unos Aspectos de la Flora Util de Guatemala

Acción Diurética y Antimicrobiana de Algunos Vegetales del Género Smilax (Tesis)

Acción Diurética de Algunas Plantas de Guatemala (Tesis)

Sistema para la revalidación, investigación y comercialización de las plantas medicinales en Guatemala

Estudios sobre medicina popular en Guatemala

Medicina Tradicional

Estudios colaborativos y transferencia tecnológica sobre plantas medicinales entre USAC/CEMAT

Perspectiva

Usos de las Plantas Medicinales de México

Las plantas medicinales del departamento de Alta Verapaz

Anales de la Sociedad de Geografía e Historia de Guatemala

Las plantas medicinales del departamento de Alta Verapaz

Anales de la Sociedad de Geografía e Historia de Guatemala

Especies Utiles de la Flora Salvadoreña

Clinical Chemistry: Principles and Technics

Botanical remedies of South and Central America, and the Caribbean: an archival analysis

Journal of Ethnopharmacology

Aspectos de la medicina popular en el área rural de Guatemala

Guatemala Indígena