Study of β-cyclodextrin and ethylated β-cyclodextrin salbutamol complexes, in vitro evaluation of sustained-release behaviour of salbutamol

doi:10.1016/0378-5173(96)04624-8

International Journal of Pharmaceutics

Volume 141, Issues 1–2, 6 September 1996, Pages 117-124

https://doi.org/10.1016/0378-5173(96)04624-8 Get rights and content

Abstract

Solid complexes of salbutamol with β-cyclodextrin (β-CD) and different batches of ethylated β-cyctodextrin (Et-β-CD) in a 1 : 1 molar ratio were prepared by the freeze-drying method. Inclusion complexation of salbutamol with all the CD used was confirmed in the solid state by differential scanning calorimetry (DSC), and in aqueous solution by circular dichroism analysis and electrospray mass spectrometry (ES-MS). The dissolution rate of salbutamol from the inclusion complexes was determined in water. We discuss the behaviour of the dissolution profiles obtained, since the Et-β-CD complexes displayed a slower release of salbutamol compared with the β-CD complex.

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Research paperStudy of β-cyclodextrin and ethylated β-cyclodextrin salbutamol complexes, in vitro evaluation of sustained-release behaviour of salbutamol

Abstract

J. Pharm. Sci.

Carbohydr. Res.

J. Pharm. Sci.

J. Pharm. Sci.

J. Pharm. Sci.

Int. J. Pharm.

Carbohydr. Res.

Interaction of triamterene with hydroxypropyl β-cyclodextrin in ground mixtures, improvement in the dissolution properties

Characterisation of the complexation behaviour of lipophilic cyclodextrins by electrospray mass spectrometry

J. Chem. Soc., Chem. Commun.

Circular dichroism study of the cyclodextrin-mediated aggregation of cyanine dyes

Studies of cyclodextrin inclusion complexes. I. The salbutamol-cyclodextrin complex as studied by phase solubility and DSC

Int. J. Pharm.

Studies of cyclodextrin inclusion complexes. II. Molecular modelling and 1H-NMR evidence for the salbutamol-β-cyclodextrin complex

Int. J. Pharm.

Calorimetric studies of the interaction of 4-biphenylacetic acid and its fl-cyclodextrin inclusion compound with lipid model membrane

Int. J. Pharm.

Inclusion complexation of hydrocortisone butyrate with cyclodextrins and dimethyl-fl-cyclodextrin in aqueous solution and in solid state

Int. J. Pharm.

A study of β-cyclodextrin inclusion complexes with optically active alkyl p-tolyl sulfoxides by fast atom bombardment mass spectrometry

Pol. J. Chem.

Pharmaceutical uses of cyclodextrins and derivatives

Drug Der. Ind. Pharm.

Research paper
Study of β-cyclodextrin and ethylated β-cyclodextrin salbutamol complexes, in vitro evaluation of sustained-release behaviour of salbutamol

Studies of cyclodextrin inclusion complexes. II. Molecular modelling and ¹H-NMR evidence for the salbutamol-β-cyclodextrin complex