Evaluation of non-sink dialysis methods for the measurement of drug release from colloids: effects of drug partition

doi:10.1016/0378-5173(89)90062-8

International Journal of Pharmaceutics

Volume 56, Issue 1, 1 November 1989, Pages 71-74

https://doi.org/10.1016/0378-5173(89)90062-8 Get rights and content

Abstract

The technique of non-sink dialysis across a membrane has been used in the past for determining the release profiles of drugs from colloidal formulations. It is demonstrated that in most cases the results obtained are in fact independent of the release rate, and that the observed release rate is solely dependent on the partition coefficient of the drug between the colloid and its continuous phase. It is suggested that this may form a useful method for measuring partition in disperse systems.

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View full text

Evaluation of non-sink dialysis methods for the measurement of drug release from colloids: effects of drug partition

Abstract

Pharmacological evaluation of an injectable prolonged release emulsion of physostigmine in rabbits

J. Pharm. Pharmacol.

Potential use of albumin microspheres as a drug delivery system. I. Preparation and in vitro release of steroids

Int. J. Pharm.

Dosage form characteristics of microsphere-in-oil emulsions. 1: Stability and drug release

Chem. Pharm. Bull.

Attachment of antibiotics to nanoparticles: preparation, drug release and antimicrobial activity in vitro

Int. J. Pharm.