ArticleInhibition of central GABAA receptors enhances hepatic glucose production and peripheral glucose uptake
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GABA dramatically improves glucose tolerance in streptozotocin-induced diabetic rats fed with high-fat diet
2018, European Journal of PharmacologyCitation Excerpt :Other studies reported that insulin sensitivity was not altered, while glucose tolerance was significantly improved (Palak and Dipa, 2013). Lang and colleagues reported that injection of intra cerebroventricular GABA antagonist increased glucagon level and gluconeogenesis and led to hyperglycemia (Lang, 1995). This finding raises the question of possible brain-mediated effects of GABA on islet secretion and possibly, insulin resistance.
The hypothalamic clock and its control of glucose homeostasis
2010, Trends in Endocrinology and MetabolismCitation Excerpt :Published data on the hypothalamic control of peripheral glucose uptake (other than that induced by the mass action of glucose) are scarce. ICV injections of NMDA cause a profound increase of glucose uptake in muscle tissue [28]. The effect of NMDA was neurally mediated and independent of circulating insulin levels.
Chapter 17: The hypothalamic clock and its control of glucose homeostasis
2006, Progress in Brain ResearchCitation Excerpt :Together, these functional studies demonstrate that a stimulation of neuronal activity in the PVN results in hyperglycemia through an activation of the sympathetic input to the liver. In our experiments hepatic glucose production was not assessed directly, but previously Lang (1995) had demonstrated a stimulatory effect of intracerebroventricularly applied BIC on portal glucose levels using the euglycemic clamp technique. Moreover, our data fit in nicely with previous experiments showing increased glucose production or glucose release by the liver upon electrical stimulation of its sympathetic input (Shimazu, 1996; Takahashi et al., 1996; Nonogaki, 2000).
Maternal flaxseed diet during lactation changes adrenal function in adult male rat offspring
2015, British Journal of Nutrition