Age-related changes in expression of ampa-selective glutamate receptor subunits: Is calcium-permeability altered in hippocampal neurons?
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Cited by (63)
Insight into cognitive decline from Zn<sup>2+</sup> dynamics through extracellular signaling of glutamate and glucocorticoids
2016, Archives of Biochemistry and BiophysicsCitation Excerpt :The levels of messenger RNA encoding the AMPA-selective glutamate receptor subunit-1, GluR1 and GluR2 are the highest in the dentate gyrus, followed by the CA1 and CA3 hippocampal subfields [77], suggesting that the dentate gyrus is susceptible for the influx of Ca2+ and Zn2+. The GluR1/GluR2 messenger RNA ratios, an index of calcium-permeable AMPA receptors, are increased in the aged hippocampus, suggesting that intracellular Zn2+ dyshomeostasis, in addition to intracellular Ca2+ dyshomeostasis, may contribute to age-related neuronal death in the hippocampus including the dentate gyrus [77], which may be linked to cognitive decline in elderly people (Fig. 1). The social behavioral deficits are accompanied by a change in AMPA receptor composition, which is regulated by the brain-enriched microRNA-124, leading to an imbalance between calcium-permeable and calcium-impermeable AMPA receptors [89].
Mammalian Target of Rapamycin (mTOR), Aging, Neuroscience, and Their Association with Aging-Related Diseases
2016, Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic StrategiesEarly onset of cognitive impairment is associated with altered synaptic plasticity and enhanced hippocampal GluA1 expression in a mouse model of depression
2015, Neurobiology of AgingCitation Excerpt :Furthermore, age-related changes in hippocampal synaptic plasticity have been shown to correlate with altered patterns of glutamate neurotransmission (Barnes, 1979; Barnes and McNaughton, 1980; Barnes et al., 2000; Gleichmann et al., 2011). Changes in expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunit GluA1 associated with aging were suggested to lead to changes in synaptic plasticity (Kim et al., 2005) and may be associated with age-dependent cognitive impairment (Pagliusi et al., 1994). In addition, the implication of AMPAR current in age-related changes in memory formation was supported by the recovery of age-related cognitive decline in rats via treatment with an AMPAR modulator (Bloss et al., 2008).
Synaptic Correlates of Aging and Cognitive Decline
2013, The Synapse: Structure and FunctionDietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain
2007, Neurobiology of AgingCitation Excerpt :The calcium permeability of AMPA receptors is determined by the GluR2 subunit [43]. This subunit declines during ageing [51], potentially altering the cellular calcium dynamics. The altered calcium flux may contribute to the neurodegeneration associated with ageing [16].