Mg2+ Administered up to twenty-four hours following reperfusion prevents ischemic damage of the CA1 neurons in the rat hippocampus
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2021, Life SciencesCitation Excerpt :In this study, magnesium chloride was injected into the hippocampus of rats 10 min prior to ischemia or at 0, 2, 12, 24, or 48 h post-ischemia. Magnesium supplementation into the brain parenchyma within 24 h after ischemia can significantly improve neuronal death caused by cerebral ischemia [162]. Another study of magnesium supplementation into the brain parenchyma used magnesium sulfate, infusion of which into the hippocampal CA1 area increased the survival rate of neurons within the area after ischemia [163].
Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies
2016, Brain ResearchCitation Excerpt :The use of Mg2+ therapies to promote recovery of function has been investigated for several decades. Treatment with magnesium has been used in models of ischemia (Izumi et al., 1991; Tsuda et al., 1991; Vacanti and Ames, 1984), focal cortical lesions (Hoane et al., 2000, 1998, 1997; Hoane and Barth, 2001, 2002), and spinal cord injuries (Kwon et al., 2010) to highlight but a few of many studies. In experimental TBI, previous work has identified that dietary deficiencies in Mg2+ lead to poorer functional outcomes and increased cell death; however, some of these deficits can be rescued by Mg2+ administration and supplementation post injury (Heath and Vink, 1999; Hoane et al., 2008a; McIntosh et al., 1988).
Magnesium treatment and spontaneous mild hypothermia after transient focal cerebral ischemia in the rat
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2008, Journal of Clinical NeuroscienceCitation Excerpt :Magnesium is a well-documented neuroprotective agent in experimental brain and spinal cord injury.7,9 Experimental studies have shown the neuroprotective effect of magnesium treatment after focal and global brain ischemia,6,8,23 traumatic brain injury,9 acute spinal cord contusion7 and subarachnoid hemorrhage.24 Kaptanoglu et al. demonstrated that magnesium sulphate protects the blood-spinal cord barrier, improves clinical recovery, and protects spinal cord ultrastructure in experimental spinal cord injury in rats.7
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