Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate

General Pharmacology: The Vascular System

Volume 27, Issue 4, June 1996, Pages 629-633

1.
1. Eugenol (3-methoxy-4-hydroxy-propenylbenzene) or sodium eugenol acetate (4-0-acetic acid sodium-3-methoxy-l-propenylbenzene) (0.25, 0.5, 1 mM) concentration-dependently inhibited arachidonic acid (AA)., collagen-, epinephrine- and ADP-induced platelet aggregation.
2.
2. Eugenol or sodium eugenol acetate inhibited collagen-induced aggregation of washed rabbit platelets synergistically with creatine phosphatelcreatine phosphokinase (CP/CPK, 5 mM/10 U/ml) or p-bromophenacyl bromide (p-BPB, 10 μM), and they also potentiated the inhibitory action of imidazole (0.5 mM) on AA-induced aggregation.
3.
3. Eugenol or sodium eugenol acetate (0.25, 0.5, 1 mM) concentration-dependently inhibited AA-induced thromboxane B₂ and prostaglandin E₂ formation.
4.
4. The rise of intracellular Ca²⁺ caused by collagen, epinephrine, ADP, and AA were inhibited by eugenol or sodium eugenol acetate (1 mM).

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^☆: This study was supported by a research grant from the National Science Council of the Republic of China, Taiwan (NSC-83-0412-B-037-003).