General paperProtein profile of the myelin membrane of the fruit bat Rousettus aegyptiacus
References (14)
- et al.
Protein measurement with the Folin phenol reagent
J. biol. Chem.
(1951) - et al.
Protein composition of myelin from brain and spinal cord of several species
Brain Res.
(1973) - et al.
Comparative electrophoretic study of the Wolfgram proteins in myelin from several Mammalia
Brain Res.
(1980) - et al.
Tissue vitamin B12 assay by a radioisotope dilution technique
Clin. Chim. Acta
(1975) - et al.
Proteins of myelin and their metabolism
Neurochem. Res.
(1978) - et al.
Biochemical maturation of the central nervous system II. Protein and proteolytic enzyme changes
Brain Res.
(1970) - et al.
The use of chicken serum for measurement of serum vitamin B12 concentrations by radioisotope dilution: Description of method and comparison with microbiological assay results
Br. J. Haemat.
(1974)
Cited by (10)
White matter changes in chronic alcoholic liver disease: Hypothesized association and putative biochemical mechanisms
2015, Medical HypothesesCitation Excerpt :In essence, this mechanism suggests that decreased methylation is a direct result of a decrease in the SAM:SAH ratio. However, empirical measurement of methylation in animal models such as the B12-deficient fruit bat showed no decrease in methylation of lipids or proteins, and no change in the myelin membrane protein profile in comparison to controls [4,56–58]. Further papers have corroborated these results and directly demonstrated—in rats exposed to N2O and in fruit bats with diet-induced B12 deficiency neuropathy—that there was no evidence of decreased methylation of myelin basic protein in comparison to control animals [59].
Nitrous oxide-induced B<inf>12</inf> deficiency myelopathy: Perspectives on the clinical biochemistry of vitamin B<inf>12</inf>
2011, Journal of the Neurological SciencesCitation Excerpt :Once again, although the above mechanism seems both rational and well supported, there remain serious questions regarding its validity as a full explanation for the development of B12 deficiency myelopathy. For example, the methylation ratio mechanism is not supported in the fruit bat animal model [45]. In bats with severe B12 deficiency myelopathy due to a combination of dietary deprivation and N2O exposure, there were no significant changes in SAM and SAH levels in the brain and spinal cord, and no significant changes in the SAM:SAH ratio in comparison to control animals.
The fruit bat as an experimental model of the neuropathy of cobalamin deficiency
1987, Comparative Biochemistry and Physiology -- Part A: PhysiologyTissue vitamin B<inf>12</inf> levels in bat sucklings (Trousettus aegyptiacus) born of vitamin B<inf>12</inf> deficient mothers
1986, Comparative Biochemistry and Physiology -- Part B: Biochemistry andRecreational Nitrous Oxide Abuse: Prevalence, Neurotoxicity, and Treatment
2021, Neurotoxicity Research