Elsevier

Neuroscience Letters

Volume 185, Issue 1, 6 February 1995, Pages 60-64
Neuroscience Letters

Segmental localisation of the relays mediating crossed inhibition of hindlimb motoneurones from group II afferents in the anaesthetized cat spinal cord

https://doi.org/10.1016/0304-3940(94)11225-8Get rights and content

Abstract

We have investigated the location of the spinal neurones mediating crossed inhibition from group II afferents. Short latency IPSPs are evoked in hindlimb extensor motoneurones by stimulation of specific contralateral limb nerves at stimuli sufficient to activate group II muscle afferents. Reversible or irreversible interruption of the dorsal columns in the fifth lumbar segment (L5) dramatically attenuated the crossed inhibition. It therefore appears that the central pathway mediating this crossed inhibition involves an interneuronal relay located in the L5 segment or further rostrally. As a consequence of this anatomy, the short central latency of the crossed IPSPs suggests that a single interneurone is involved.

References (7)

There are more references available in the full text version of this article.

Cited by (21)

  • Perceptual inference

    2015, Neuroscience and Biobehavioral Reviews
    Citation Excerpt :

    They target dorsal horn and laminar VIII commissural interneurons that may also receive group Ib input (Jankowska and Edgley, 2010) and which are part of the central pattern generator for locomotion. A subset of these interneurons cross over to the opposite side of the spinal cord to synapse on motoneurons (Aggelopoulos and Edgley, 1995). Proprioceptive sensory feedback mediates the transition between the stance and swing phases of the step cycle (Lundberg et al., 1987; Edgley and Jankowska, 1987; Edgley et al., 1988; Schomburg et al., 1998).

  • Passive or simulated displacement of one arm (but not its mirror reflection) modulates the involuntary motor behavior of the other arm

    2015, Neuroscience
    Citation Excerpt :

    In both cases, the contralateral inhibition is supposed to be mediated by primary endings. Cutaneous (Aggelopoulos and Edgley, 1995) and tendinous (Frigon and Rossignol, 2008) activations, which might also be activated by either passive or simulated displacement in Experiments 1 and 2, are also at the origin of crossed effects. Although speculative, the involvement of such cross effects which can either facilitate or inhibit the Kohnstamm phenomenon, in the present experiments cannot be fully discarded.

View all citing articles on Scopus
View full text