ReviewRegulation of the immunoglobulin gene transcription
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Cited by (19)
Potentiation of humoral immune response and activation of NF-κB pathway in lymphocytes in experimentally induced hyperthyroid rats
2005, Cellular ImmunologyCitation Excerpt :But the mechanism is still to be clearly elucidated. The promoter site of immunoglobulin genes has a binding site for NF-κB [13,14]. As discussed in Section 1, NF-κB plays a major role in T and B lymphocyte functions.
An E-box Motif Residing in the Exon/Intron 1 Junction Regulates Both Transcriptional Activation and Splicing of the Human Norepinephrine Transporter Gene
2001, Journal of Biological ChemistryCitation Excerpt :This sequence therefore does not belong to the category of classical enhancers, the action of which are independent of position, orientation, or distance in relation to the transcription start site (29). It is increasingly recognized that transcription of some mammalian genes can be influenced by intronic sequences (30-35), and many of them contain important regulatory sequences in the first intron. For example, the first intron (1.8 kb) of the aldolase B gene was shown to be crucial for tissue-specific expression, independent of position and orientation (31).
Augmented humoral immune function in metallothionein-null mice
2000, Toxicology and Applied PharmacologyAn intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM τ
1995, Journal of Biological Chemistry