Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis
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Cited by (74)
Anatomy and Physiology of the Male Reproductive System and Potential Targets of Toxicants
2018, Comprehensive Toxicology: Third EditionThe Leydig Cell as a Target for Toxicants
2018, Comprehensive Toxicology: Third EditionRelationship between serum dioxin-like polychlorinated biphenyls and post-testicular maturation in human sperm
2017, Reproductive ToxicologyCitation Excerpt :Further studies on the effect of DL-PCB exposure -both individual congeners and PCB mixtures - on male accessory glands are required. Interestingly, the lack of correlation between serum PCB levels and both the total sperm count and sperm concentration (for the entire group as well as the individual groups studied) was similar to those obtained in other mammals like adult male rats, in which exposure to TCDD at relatively high doses caused a decrease in weight of two androgen-sensitive organs (seminal vesicles and epididymis) without affecting spermatogenesis [44]. Similarly, studies performed with human adult males suggest no relationship between dioxin-like activity and sperm concentration [19].
Spermatogenesis disruption by dioxins: Epigenetic reprograming and windows of susceptibility
2017, Reproductive ToxicologyCitation Excerpt :Tolerable daily intake of DLCs established by WHO was derived from an exposure dose 0.064 μg TCDD/kg on gestational day 15 that resulted in a significant decrease of epididymal sperm count in rats [42]. Adverse effects of dioxins on Leydig cells were observed at higher doses in marmosets [43] and rodents [44]. Decrease in epididymal sperm count was demonstrated in many other experimental studies [45–49].
Expression of nerve growth factor and its receptor, tyrosine kinase receptor A, in rooster testes
2015, Animal Reproduction ScienceCitation Excerpt :Immunoreactivity for NGF was detectable in Leydig cells and germ cells, indicating that NGF may be involved in different cellular events in rooster testes. It is well known that interactions between germ cells and Sertoli cells, as well as regulators produced from Leydig cells, are crucial for spermatogenesis (Johnson et al., 1992; Nayernia et al., 1999; Fok et al., 2014). Since TrkA is expressed in somatic Sertoli cells and NGF is expressed in Leydig cells, we hypothesized that NGF produced from Leydig cells may interact with TrkA in the membrane of Sertoli cells, to influence the function of Sertoli cells.
The Leydig Cell as a Target for Toxicants
2010, Comprehensive Toxicology, Second Edition