Specialist interest article
Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma

https://doi.org/10.1016/0277-5379(91)90379-RGet rights and content

Abstract

We investigated the expression of the neural cell ahesion molecule (NCAM) in a series of surgically resected lung carcinomas of various histological subtypes by means of a panel of monoclonal antibodies recognising different N-CAM epitopes. In a subgroup of 56 tumours, the results of immunostaining with MAb 123C3—the antibody studied most extensively in our material—were compared to the ultrastructure, and in 231 radically resected non-small cell carcinomas, with histological tumour type and with clinical follow-up data. N-CAM expression was not limited to neuroendocrine tumours, as assessed ultrastructurally. Non-small cell lung carcinomas positive for MAb 123C3 showed post-operative overall and disease-free survival times significantly shorter than 123C3-negative non-small cell carcinomas.

References (20)

  • PCL Beverley et al.

    Results of the central data analysis

    Lung Cancer

    (1988)
  • WJ Mooi et al.

    Monoclonal antibody 123c3 in lung tumour classification: immunohistology of 358 resected lung tumours

    Mol Cell Probes

    (1988)
  • CF Mountain

    Staging in lung cancer, UICC 1987

    Chest

    (1986)
  • World Health Organization

    The World Health Organization Histological Typing of Lung Tumours

    (1981)
  • CEC Moolenaar et al.

    Expression of an N-CAM related sialoglycoprotein in small cell lung cancer and neuroblastoma

    Cancer Res

    (1990)
  • D Bitter-Suermann et al.

    Monoclonal antibodies to polysialic acid reveal epitope sharing between invasive pathogenic bacteria, differentiating cells and tumor cells

    Immunol Res

    (1987)
  • J Roth et al.

    Reexpression of poly(sialic acid) units of the neural cell adhesion molecule in Wilms' tumor

  • J Kruse et al.

    Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1

    Nature

    (1984)
  • V Kunemund et al.

    The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions

    J Cell Biol

    (1988)
  • AF Gazdar et al.

    Establishment of continuous, clonable cultures of small-cell carcinoma of the lung which have amine precursor uptake and decarboxylation cell properties

    Cancer Res

    (1985)
There are more references available in the full text version of this article.

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