PaperRe-investigation of the circumsporozoite protein-based induction of sterile immunity against Plasmodium berghei infection
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Cited by (21)
Modelling the roles of antibody titre and avidity in protection from Plasmodium falciparum malaria infection following RTS,S/AS01 vaccination
2020, VaccineCitation Excerpt :Antibody avidity measured using inhibition ELISAs is a representation of the overall strength of interaction between antibodies and antigens in a complex, it takes into account the intrinsic affinity of antibodies to their specific epitopes and also valences of antibodies and any structural features of antibody binding confirmations [26–28]. High avidity antibodies have been shown to be important in the protection conferred by several viral and bacterial vaccines [29–33] but studies of antibody avidity responses following 012M RTS,S vaccination during field trials have provided conflicting evidence on the relationship between avidity and protection from infection thus far [34–37]. Here we re-analyse the immunological data from the delayed-fractional challenge trial using a biologically-motivated mathematical model of P. falciparum sporozoite inoculation [10].
Irradiated sporozoite vaccination induces sex-specific immune responses and protection against malaria in mice
2019, VaccineCitation Excerpt :Preclinical animal models have proven useful for studying vaccine efficacy and the immune response to malaria [14]. Little consideration, however, has been given to sex as a biological variable, with most studies either not reporting the sex of the animals or only using female animals [15–18]. In murine studies of malaria blood stage infection, females have reduced mortality, experience faster resolution of infection-associated anemia and weight loss, and mount a more robust immune response to infection (e.g. increased IFNƴ, IL-10, and Plasmodium specific IgG1 antibody production) than males [19].
Molecular adjuvants for malaria DNA vaccines based on the modulation of host-cell apoptosis
2009, VaccineCitation Excerpt :Following the discovery of CSP-specific cytotoxic effector T cells in the P. yoelii model [33], a significant effort was made to demonstrate an equivalent cell population after immunization with P. berghei-CSP-vaccines. Despite the identification of putative MHC-I epitopes on the P. berghei CS protein and the identification of irradiated sporozoite-induced CD8 effector cells in the liver that secrete NOS and IFN-γ [34], it appears that antibodies are the main effector molecules in this disease model [27,35] while CD8 T cells – at least in certain models of P. berghei – are linked to pathogenesis, not protection [36]. Studies designed to address this question, however, have been hampered by the parasites sensitivity to changes in the host's immune status.
Malaria vaccines for travelers
2004, Travel Medicine and Infectious DiseasePeptide-based subunit vaccines against pre-erythrocytic stages of malaria parasites
2001, Molecular Immunology