T cell-macrophage interaction in arginase-mediated resistance to herpes simplex virus

doi:10.1016/0168-1702(84)90007-8

Virus Research

Volume 1, Issue 6, September 1984, Pages 501-505

https://doi.org/10.1016/0168-1702(84)90007-8 Get rights and content

Abstract

Peritoneal macrophages activated by-products derived from a herpes simplex virus-specific helper T cell clone were used to investigate intrinsic and extrinsic resistance mechanisms to herpes simplex virus type 1 infection in vitro. T cell-activated macrophages produced fewer infective centres, indicating enhanced intrinsic resistance, and markedly reduced the growth of virus in a permissive cell line. The reduction in virus growth correlated with the depletion of arginine in the support medium, presumably resulting from increased arginase production by activated macrophages. The significance of these findings for antiviral immunity in vivo is discussed.

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T cell-macrophage interaction in arginase-mediated resistance to herpes simplex virus

Abstract

Cell Immunol.

Cell Immunol.

Cell Immunol.

Immunobiology

Tumor-dependent resistance of rat peritoneal macrophages to herpes simplex virus

Infect. Immun.