In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations

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Abstract

The food components chlorophyllin, β-carotene and α-linolenic acid (in its methyl ester form) were tested in Chinese hamsters for antimutagenic activity on the powerful mutagen thio-tepa. Each of these natural protective compounds inhibited by 70–85% the clastogenic effects induced by the mutagen. When 2 or 3 of these antimutagens were administered simultaneously no additive effects were observed. α-Linolenic acid methyl ester was the most effective antimutagen under the experimental conditons.

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