In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations
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Translocation and chronic effects of microplastics on pea plants (Pisum sativum) in copper-contaminated soil
2022, Journal of Hazardous MaterialsCitation Excerpt :In the case of Cu, in a state exposed to copper, Cu2+ accumulated in plants is replaced by Mg2+ destroying the phytol group. Therefore, chlorophyll is converted to chlorophyllin, and it has a more stable molecular structure than chlorophyll and is darker than chlorophyll (Ong et al., 1986, 1989; Whong et al., 1988; Renner, 1990; Warner et al., 1991; Sarkar et al., 1996; Aparicio-Ruiz et al., 2011). Owing to the above structural change, Cu exhibited the darkest green.
A comparative study of the anticlastogenic effects of chlorophyllin on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or 7,12-dimethylbenz (α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo
2012, Toxicology LettersCitation Excerpt :Studies on the inhibition of the genotoxic damage induced by environmental agents have been carried out in the last 15 years, particularly because anti-genotoxic agents may also reduce incidence of cancer in humans (De Flora, 1998). Anti-clastogenic activity of CHL has also been demonstrated in several in vivo studies with rodents (Sarkar et al., 1994; Renner, 1990; Abraham et al., 1994). It has been shown that CHL can substantially reduce tumor response in target organs in a variety of animal models.
Preliminary study on inhibition of genotoxicity by piperine in mice
2005, FitoterapiaThe mutagenic potentiator effect of chlorophyllin by the HGPRT assay
2004, Toxicology in Vitro