Induction of micronuclei in the mouse: Revised timing of the final stage of erythropoiesis
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A critical examination of the mode of action of quinacrine in the reproductive tract in a 2-year rat cancer bioassay and its implications for human clinical use
2015, Regulatory Toxicology and PharmacologyCitation Excerpt :It did not induce micronuclei (MN) in rodent bone marrow (Clarke et al., 2001) or chromosome aberrations in cynomolgus monkey lymphocytes (Blake et al., 1983). Although there had been earlier reports of MN induced in rodent bone marrow cells (Hart and Hartley-Asp, 1983; Jenssen et al., 1974), these effects were contradicted by subsequent studies that demonstrated that the cellular inclusions scored as MN in those studies were actually quinacrine, or other, inclusions, and not MN (Ashby et al., 1990; Hitotsumachi et al., 1990; Maier and Schmid, 1975). Quinacrine’s genetic activity in vitro has been attributed to its ability to intercalate into the DNA helix without forming an adduct (Ferguson and Denny, 2007).
Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins
2004, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisStochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay
2001, Mathematical BiosciencesCitation Excerpt :Therefore it is difficult to estimate a priori this parameter. Estimates of the mean time duration of maturation phases are generally situated between 6 and 10 h [3,4,25,26]. Jenssen and Ramel [1] found that the time from DNA synthesis step to nucleus expulsion lasts about 12 h, meaning time for G2 and mitosis was 2–6 h.
Micronucleated erythrocytes in splenectomized patients with and without chemotherapy
1996, Mutation Research - Environmental Mutagenesis and Related SubjectsRadioprotection of β-carotene evaluated on mouse somatic and germ cells
1996, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisSpontaneous micronuclei in peripheral blood erythrocytes from 35 mammalian species
1996, Mutation Research - Genetic Toxicology