History and current uses of 224Ra in ankylosing spondylitis and other diseases
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Cited by (18)
Radiobiology of Targeted Alpha Therapy
2022, Nuclear Medicine and Molecular Imaging: Volume 1-4Carcinogenicity of metal compounds
2021, Handbook on the Toxicology of Metals: Fifth EditionThe impact of barium isotopes in radiopharmacy and nuclear medicine – From past to presence
2021, Nuclear Medicine and BiologyCitation Excerpt :The heaviest group 2 element radium delivers two isotopes of high relevance for targeted alpha therapy: 223Ra and 224Ra. For a number of decades in the past, 224Ra (t1/2 = 3.6 d) has been applied as SpondylAT® for the treatment of Morbus Bechterew [11,12], but lost its approval in 2006 due to regulatory issues. Moreover, a study with 1471 ankylosing spondylitis patients who have received SpondylAT® pointed out the risk to develop myeloproliferative diseases [13].
Carcinogenicity of metal compounds
2021, Handbook on the Toxicology of Metals: Volume I: General ConsiderationsRadionuclide calibrator responses for <sup>224</sup>Ra in solution and adsorbed on calcium carbonate microparticles
2020, Applied Radiation and IsotopesCitation Excerpt :This property leads radium to target osteoblastic bone metastases (Sartor et al., 2013). The bone-seeking property of radium as 224Ra was exploited medically over many years (1950–2005) (Koch, 1978; Kommission Pharmakotherapie, 2001; Wick and Gössner, 1993; Eckert and Ziegler, 2006), although not in cancer therapy but as palliative treatment for ankylosing spondylitis disease. Nowadays, another α-emitting radium isotope, 223Ra-dichloride (Xofigo, Bayer)†, is used for treatment of patients with skeletal metastases from castration-resistant prostate cancer (Kluetz et al., 2014).
Primary standardization of <sup>224</sup>Ra activity by liquid scintillation counting
2020, Applied Radiation and IsotopesCitation Excerpt :Poor knowledge of the effects of ionizing radiation, particularly on growing and developing tissues, likely account for many of the very serious reported side-effects (e.g., Spiess, 2002). Difficulties were probably also compounded by the lack of a reliable method for measuring activity, which was initially calculated in electrostatic units, an obsolete unit used until 1969 for 224Ra medical dosage (Wick and Gössner, 1993). More recently, a suspension of injectable calcium carbonate microparticles labeled with 224Ra has shown promise in preclinical studies for treatment of cavitary micro-metastatic cancer (Westrøm et al., 2018, 2018b).