Cell
ArticleCraniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice
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The molecular basis of neural crest axial identity
2018, Developmental BiologyCitation Excerpt :These proteins are essential for posterior neural tube closure and migration of neural crest cells originating therein. Interestingly, ubiquitous expression of Hoxa7 results in severe craniofacial defects (Balling et al., 1989), which highlights how the topological restriction of specific Hox genes recapitulates anatomical differences inherent in neural crest cells. Additionally, unlike members of Hox1–Hox5 family, the above proteins respond to FGF signaling and not retinoic acid signaling (Nelms and Labosky, 2010), which is supportive of the hypothesis that environmental cues contribute to differences in development of neural crest subpopulations.
The chick embryo as a model for the effects of prenatal exposure to alcohol on craniofacial development
2016, Developmental BiologyCitation Excerpt :The rostrocaudal axis of the developing embryo is patterned by the nested expression of homeobox genes of the HOX family in multiple tissues including the neural tube, neural crest and pharyngeal arches (Trainor and Krumlauf, 2001). RA disrupts this HOX code by ectopically activating HOX gene expression, leading to changes in neural crest and pharyngeal arch specification that can ultimately result in craniofacial abnormalities (Balling et al., 1989; Morriss-Kay et al., 1991; Marshall et al., 1992; Alexandre et al., 1996; Pasqualetti et al., 2000). Later stages of craniofacial development are still under the control of secreted signalling factors.
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2016, Trends in Biochemical SciencesCitation Excerpt :Developmental regulators are generally expressed in a tissue- and stage-specific manner to modulate patterning, differentiation, and proliferation. Morphological and/or functional defects in loss-of-function and gain-of-function mutants suggest that both the repression and activation of these genes are equally crucial for normal development and lifelong tissue homeostasis [1–4]. Notably, this also implies that there could be evolutionarily conserved mechanisms to ensure the developmental regulators are robustly regulated.
Cancer cell metabolism and developmental homeodomain/POU domain transcription factors: A connecting link
2015, Cancer LettersCitation Excerpt :In the perspective of the involvement of transcription factors in the metabolic pathway of neoplastic cells, transcription factors involved in different developmental processes also draws attention as neoplastic cells and stem cells share similar properties and both the processes of cellular proliferation and metabolism are tightly linked. The proteins coded by homeobox genes are one of the major groups of transcription factors controlling cellular differentiation during the vital phase of an organism’s life, that is development [38–40]. Apart from the important developmental functions of homeoproteins, they have also been observed in manifestation of neoplastic phenotype of different tissues [41,42].