Original articleFurther studies on the mechanism of suppression of human lymphocyte transformation by human alpha fetoprotein☆
References (37)
- et al.
Suppression of the primary cell-mediated immune response by human α-fetoprotein in vitro
Cell Immunol
(1977) - et al.
The effect of purified α-fetoprotein on in vitro assays of cell-mediated immunity
Cell Immunol
(1977) - et al.
Studies on human α-fetoprotein. Isolation and characterization of monomeric and polymeric forms and amino-terminal sequence analysis
Biochim Biophys Acta
(1977) - et al.
Heterogeneity of human atpha-fetoprotein as revealed by isoelectric focusing in ureacontaining gels
Biochim Biophys Acta
(1978) - et al.
Human alpha-fetoprotein in the epidermal cells of Bowen's disease
J Invest Dermatol
(1978) - et al.
A modified fluorometric method for the determination of microgram quantities of DNA from cell and tissue cultures
Anal Biochem
(1976) - et al.
Solubility in aqueous solutions of ethanol of the small molecular weight peptides of the serum very low density and high density lipoproteins: Relevance to the recovery problem during delipidation of serum lipoproteins
Anal Biochem
(1971) Interaction of prostaglandins with blood plasma proteins. I. Binding of prostaglandin E2 to human plasma proteins and its effect on the physiological activity of prostaglandin E2 in vitro and in vivo
Biochem Biophys Acta
(1972)Demonstration of the inhibitory effect of human alpha fetoprotein on in vitro human lymphocyte transformation
- et al.
Inhibition of human lymphocyte transformation by human alpha fetoprotein (HAFP); comparison of foetal and hepatoma HAFP and kinetic studies of in vitro immunosuppression
Clin Exp Immunol
(1976)
Human alpha fetoprotein as a modulator of human lymphocyte transformation: Correlation of biological potency with electrophoretic variants
A postsynthetic modification of human α-fetoprotein controls its immunosuppressive potency
Inhibition of human lymphocyte transformation by human α-fetoprotein (HAFP); HAFP monomers and multimers and a resistant lymphocyte subpopulation
J Immunol
Inhibition of human lymphocyte transformation by human alpha fetoprotein (HAFP): Studies on the mode of HAFP action and the role of HAFP polymorphism
Immunology
α-Fetoprotein and human lymphocyte svbpopulations
J Immunol
Conditions affecting the immunosuppressive properties of human α-fetoprotein
J Immunol
Augmentation of proliferation of human mixed lymphocyte culture by human alpha-fetoprotein
J Immunol
Human alpha-fetoprotein: Immunosuppressive activity and microheterogeneity
Immunol Commun
Cited by (27)
Immunomodulatory impact of α-fetoprotein
2022, Trends in ImmunologyCitation Excerpt :The proposed mechanisms for these suppressive functions may include: (i) the transportation of immunosuppressive AFP-bound LMM species, and (ii) certain intrinsic properties of the AFP protein which may include immune cell functions. However, many apparently contradictory data from previous studies [9,10,13,17,48,49] might be the result of differences in host species, clinical conditions, tissue sources, and isolation methods (Figure 2). These differences may affect various biochemical properties, such as the removal of bound ligands, the enrichment of select isoforms, as well as the status of isoelectric points and post-translational modifications (i.e., sialylation).
Clinicopathologic characteristics and surgical outcomes of hepatocellular carcinoma with portal vein tumor thrombosis
2012, Journal of Surgical ResearchCitation Excerpt :In this study, AFP level was the most statistically significant independent risk factor for overall survival of HCC patients with PVTT who underwent surgery. A high AFP level worsens the prognosis of HCC maybe because AFP is significantly associated with the grade of malignancy and may suppress the immunologic reaction against tumor cells [32, 33]. Adjacent organ invasion was the second independent risk factor affecting the survival in HCC patients with PVTT after surgery.
Prognosis evaluation in alpha-fetoprotein negative hepatocellular carcinoma after hepatectomy: Comparison of five staging systems
2010, European Journal of Surgical OncologyCitation Excerpt :Although the specific reason for the increased AFP level worsening the prognosis is uncertain. AFP may be a unique biological variable that signifies grade of malignancy and has suppressive effects on the immunological reaction directed against tumor cells.16,17 By multivariate analysis, the overall survival of AFP negative patients largely depended on preoperative liver background by Child-Pugh classification, HBsAg status, capsule formation and BCLC stage (Table 2).
Hepatic resection for hepatocellular carcinoma in Taiwan
2002, European Journal of Surgical OncologyPurification of canine alpha-fetoprotein and alpha- fetoprotein values in dogs
1995, Veterinary Immunology and Immunopathology
- ☆
Supported by a grant from the Leukemia Research Foundation, by Grant No. 1-PO CA19266-02 awarded by the National Cancer Institute, Department of Health, Education, and Welfare, and by training grant 5 T32 AM07134-03 (National Institute of Arthritis and Metabolic Diseases). The Franklin McLean Memorial Research Institute is operated by The University of Chicago for the U.S. Department of Energy under Contract No. EY-76-C-02-0069.
- ∗
Recipient of a U.S. Public Health Service-National Canser Institute Postdoctoral Research Fellowship Award (No. 1 F 32 CA05337-02).