Cadmium, methylmercury, mercury, and lead inhibition of calf liver glutathione S-transferase exhibiting selenium-independent glutathione peroxidase activity☆
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Human-induced pluripotent stems cells as a model to dissect the selective neurotoxicity of methylmercury
2019, Biochimica et Biophysica Acta - General SubjectsInvestigation of arsenic accumulation and biochemical response of in vitro developed Vetiveria zizanoides plants
2017, Ecotoxicology and Environmental SafetyCitation Excerpt :Arsenic induced enhancement of various antioxidant enzymes like superoxide dismutase, ascorbate peroxidise, and catalase were recorded in As- tolerant plants (Srivastava et al., 2005; Singh et al., 2006; Dave et al., 2013; Kanwar and Bhardwaj, 2015). The influence of heavy metals on plant GSTs is rather poorly studied when compared to that on animal GSTs (Reddy et al., 1981). GST may serve in the intracellular detoxification of mutagens, carcinogens and other noxious chemical substances like heavy metals in plant cells (Kumar et al., 2013a, 2013b).
Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals
2012, Toxicology in VitroCitation Excerpt :Though rat studies have implicated lead in increasing GST expression and subsequent activity (Daggett et al., 1998), lead has not been shown to directly inhibit GST enzyme activity (Dierickx, 1982) as seen here with human GSTP1. Consistent with GSTs isolated from rats and calves, recombinant human GSTP1, regardless of genotype, was not inhibited by manganese chloride (Dierickx, 1982; Reddy et al., 1981). Cadmium inhibited 50% of GST activity in vitro at concentrations between 10 and 750 μM in calf liver (Reddy et al. 1981), human erythrocytes (Poon and Chu, 2000) and of GSTP1 isolated from a hepatoma cell line (Almar and Dierickx, 1990) while 200 μM decreased the activity of GSTs isolated from rat liver by 37% (Dierickx, 1982).
Effects of combined vanadate and magnesium treatment on erythrocyte antioxidant defence system in rats
2010, Environmental Toxicology and PharmacologyToxicological effects of methylmercury on walleye (Sander vitreus) and perch (Perca flavescens) from lakes of the boreal forest
2008, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology
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CAES No. 589-81.